920517
6-(4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazine-2-carboxylic acid
别名:
Rigid linker for PROTAC® development
登录并加购，请在购物车里查看协议价、货期和发货地。
选择规格
变更视图
关于此项目
经验公式（希尔记法）:
C15H22N4O4
化学文摘社编号:
分子量:
322.36
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22
reaction suitability
reagent type: linker
Quality Segment
functional group
Boc, carboxylic acid
storage temp.
2-8°C
SMILES string
CC(C)(OC(N1CCCN(C2=CN=CC(C(O)=O)=N2)CC1)=O)C
InChI
1S/C15H22N4O4/c1-15(2,3)23-14(22)19-6-4-5-18(7-8-19)12-10-16-9-11(17-12)13(20)21/h9-10H,4-8H2,1-3H3,(H,20,21)
InChI key
JBZILBWYLNAFOB-UHFFFAOYSA-N
Application
6-(4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazine-2-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920525
920681
Similar linkers in this series:
920525
920681
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable