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920673

1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazole-4-carboxylic acid

Name: 1-(1-(<I>tert</I>-Butoxycarbonyl)piperidin-3-yl)-1<I>H</I>-pyrazole-4-carboxylic acid
Brand: ALDRICH

别名:

Rigid linker for PROTAC^® development

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关于此项目

经验公式（希尔记法）:

C₁₄H₂₁N₃O₄

化学文摘社编号:

1422386-02-4

分子量:

295.33

UNSPSC Code:

12352106

NACRES:

NA.22

MDL number:

MFCD25371800

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属性

form

powder

Quality Level

100

reaction suitability

reagent type: linker

functional group

Boc, carboxylic acid

storage temp.

2-8°C

SMILES string

CC(C)(OC(N1CCCC(N2C=C(C(O)=O)C=N2)C1)=O)C

InChI

1S/C14H21N3O4/c1-14(2,3)21-13(20)16-6-4-5-11(9-16)17-8-10(7-15-17)12(18)19/h7-8,11H,4-6,9H2,1-3H3,(H,18,19)

InChI key

ZTQAPANOXVJNDD-UHFFFAOYSA-N

说明

Application

1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920533
920649
920665
920703

Other Notes

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

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全球贸易项目编号

货号	GTIN
920673-50MG	04065266033250
920673-100MG	04065266033243