主要文件

923389

1-((2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)piperidine-4-carboxylic acid

Name: 1-((2-(<I>tert</I>-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)piperidine-4-carboxylic acid
Brand: ALDRICH

别名:

Rigid linker for PROTAC^® development

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关于此项目

经验公式（希尔记法）:

C₁₈H₃₀N₂O₅

分子量:

354.44

MDL number:

MFCD34602206

UNSPSC Code:

12352106

NACRES:

NA.22

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属性

form

powder or crystals

Quality Level

100

reaction suitability

reagent type: linker

functional group

Boc, carboxylic acid

storage temp.

2-8°C

SMILES string

O=C(O)C(CC1)CCN1CC(CC2)OC32CN(C(OC(C)(C)C)=O)C3

InChI key

CVHPZSHLWZEYQS-UHFFFAOYSA-N

说明

Application

1-((2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)piperidine-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Other Notes

Protein Degrader Building Blocks

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

Practum is a registered trademark of Sartorius Lab Instruments GmbH & Co. KG

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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全球贸易项目编号

货号	GTIN
923389-50MG	04065266082951