923389
1-((2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)piperidine-4-carboxylic acid
别名:
Rigid linker for PROTAC® development
InChI key
CVHPZSHLWZEYQS-UHFFFAOYSA-N
SMILES string
O=C(O)C(CC1)CCN1CC(CC2)OC32CN(C(OC(C)(C)C)=O)C3
form
powder or crystals
reaction suitability
reagent type: linker
functional group
Boc
carboxylic acid
storage temp.
2-8°C
Quality Level
Application
1-((2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)piperidine-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Other Notes
Legal Information
Practum is a registered trademark of Sartorius Lab Instruments GmbH & Co. KG
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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