923400
4-((7-(tert-Butoxycarbonyl)-7-azaspiro[3.5]nonan-2-yl)oxy)benzoic acid
别名:
Rigid linker for PROTAC® development
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关于此项目
form
powder or crystals
Quality Segment
reaction suitability
reagent type: linker
functional group
Boc, carboxylic acid
storage temp.
2-8°C
SMILES string
OC(C1=CC=C(OC2CC3(C2)CCN(C(OC(C)(C)C)=O)CC3)C=C1)=O
InChI key
YOVVDIZHCSSGQM-UHFFFAOYSA-N
Application
4-((7-(tert-Butoxycarbonyl)-7-azaspiro[3.5]nonan-2-yl)oxy)benzoic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
923265
923249
923257
Similar linkers in this series:
923265
923249
923257
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable