923818
N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide
别名:
Coumarin alkyne CoLDR probe
反应适用性
reagent type: chemical modification reagent
reaction type: click chemistry
质量水平
官能团
(Alkyne)
储存温度
2-8°C
SMILES字符串
O=C1OC2=CC(OCC(C(NCCC#C)=O)=C)=CC=C2C=C1
InChI key
MTTOLTREJYBDSH-UHFFFAOYSA-N
应用
N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide is a proteomic cysteine probe. As described in Reddi et al, the Nir London lab developed a-substituted N-alkynyl-methacrylamides for covalent ligand directed release chemistry (CoLDR). CoLDR represents a new type of acrylamide-based electrophiles for targeted covalent inhibitor discovery and design. Specifically this CoLDR probe is a coumarin derivative with a terminal alkyne for click chemistry.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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