923958
6F,C5-Pomalidomide-4-piperidine-C1-piperazine hydrochloride
别名:
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(4-(piperazin-1-ylmethyl)piperidin-1-yl)isoindoline-1,3-dione hydrochloride, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block
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About This Item
经验公式（希尔记法）:
C23H28FN5O4 · xHCl
分子量:
457.50 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.21
ligand
6F,C5-Pomalidomide
质量水平
反应适用性
reactivity: carboxyl reactive
reagent type: ligand-linker conjugate
官能团
amine
储存温度
2-8°C
SMILES字符串
O=C1C(N2C(C(C=C(F)C(N(CC3)CCC3CN4CCNCC4)=C5)=C5C2=O)=O)CCC(N1)=O.Cl
InChI key
NSESLQMRUIXJGI-UHFFFAOYSA-N
应用
Protein degrader building block 6F,C5-Pomalidomide-4-piperidine-C1-piperazine hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a Cereblon (CRBN) recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
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其他说明
法律信息
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
警示用语：
Danger
危险声明
危险分类
Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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