925012
E7820-PEG5-NH2 hydrochloride
别名:
N-(17-amino-3,6,9,12,15-pentaoxaheptadecyl)-3-(N-(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl)benzamide hydrochloride, Crosslinker−E3 Ligase ligand conjugate, DCAF15 protein degrader building block
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经验公式（希尔记法）:
C29H39N5O8S · xHCl
分子量:
617.71 (free base basis)
NACRES:
NA.22
UNSPSC Code:
12352200
ligand
E7820
Quality Level
reaction suitability
reactivity: carboxyl reactive, reagent type: ligand-linker conjugate
functional group
amine
storage temp.
2-8°C
Application
Protein degrader builiding block E7820-PEG5-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a DCAF15-recruiting ligand E7820 (SML2950), a PEG linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Technology Spotlight: DCAF15 Degrader Building Blocks for Targeted Protein Degradation
Technology Spotlight: DCAF15 Degrader Building Blocks for Targeted Protein Degradation
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 925012-50MG | 04065267409634 |