ligand
pomalidomide
质量水平
方案
≥95%
表单
powder
官能团
amine
储存温度
2-8°C
SMILES字符串
COC1=CC(COC(N2C(CCC(N3C(C4=CC=CC(NCCN)=C4C3=O)=O)C2=O)=O)=O)=C(C=C1OC)[N+]([O-])=O
InChI
1S/C25H25N5O10/c1-38-18-10-13(17(30(36)37)11-19(18)39-2)12-40-25(35)29-20(31)7-6-16(23(29)33)28-22(32)14-4-3-5-15(27-9-8-26)21(14)24(28)34/h3-5,10-11,16,27H,6-9,12,26H2,1-2H3
InChI key
QEGZOUGKLQLVHL-UHFFFAOYSA-N
应用
Protein degrader building block Opto-pomalidomide-C2-NH2 hydrochloride enables the synthesis of molecules for light-induced targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a Cereblon (CRBN) recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
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其他说明
法律信息
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
警示用语：
Danger
危险声明
危险分类
Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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