930210
N-(2,5-Dichlorobenzoyl)glycyl-L-leucine
≥95.0%
别名:
(2S)-2-{2-[(2,5-Dichlorophenyl)formamido]acetamido}-4-methylpentanoic acid, CANDDY_MLN Tag
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关于此项目
Quality Segment
assay
≥95.0%
form
powder
storage temp.
2-8°C
SMILES string
ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(O)=O)CC(C)C)=O)=O)=C1
InChI
1S/C15H18Cl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12H,5,7H2,1-2H3,(H,18,21)(H,19,20)(H,22,23)/t12-/m0/s1
InChI key
DNIFDGIEBFRALC-LBPRGKRZSA-N
Application
CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.
CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.
CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable