Quality Segment
assay
≥95%
form
powder
technique(s)
targeted protein degradation: suitable
storage temp.
2-8°C
SMILES string
ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2=O)=O)=O)CC(C)C)=O)=O)=C1
InChI
1S/C19H21Cl2N3O6/c1-10(2)7-14(19(29)30-24-16(26)5-6-17(24)27)23-15(25)9-22-18(28)12-8-11(20)3-4-13(12)21/h3-4,8,10,14H,5-7,9H2,1-2H3,(H,22,28)(H,23,25)/t14-/m0/s1
InChI key
KCUJPSDSTWVHLQ-AWEZNQCLSA-N
Application
CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.
CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.
CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable