Pomalidomide-piperazine-acetic acid

Name: Pomalidomide-piperazine-acetic acid
Brand: ALDRICH

≥95%

别名:

2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)acetic acid, {4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}acetic acid

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About This Item

经验公式（希尔记法）:

C₁₉H₂₀N₄O₆

CAS Number:

2591180-39-9

分子量:

400.39

MDL编号:

MFCD34570945

UNSPSC代码:

12352106

NACRES:

NA.21

ligand

pomalidomide

质量水平

100

方案

≥95%

表单

powder

官能团

carboxylic acid

储存温度

2-8°C

SMILES字符串

O=C(O)CN1CCN(C2=CC=C3C(=O)N(C(=O)C3=C2)C4C(=O)NC(=O)CC4)CC1

InChI

1S/C19H20N4O6/c24-15-4-3-14(17(27)20-15)23-18(28)12-2-1-11(9-13(12)19(23)29)22-7-5-21(6-8-22)10-16(25)26/h1-2,9,14H,3-8,10H2,(H,25,26)(H,20,24,27)

InChI key

KKROJYHJCUOZOJ-UHFFFAOYSA-N

应用

Pomalidomide-piperazine-acetic acid is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with amine linkers due to the presence of a carboxyl group via peptide coupling reactions. A basic building block for development of a protein degrader library.

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