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Merck
CN

933899

N-(2-Hydroxy) propyl-3-trimethylammonium chitosan chloride

degree of quaternization 50%

别名:

Chioisan, HTCC, Quaternized Chitosan, Solube chitosan, TMC, Trimethyl chitoan

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关于此项目

线性分子式:
(C12H25N2O5Cl)n(C8H13NO5)m
NACRES:
NA.21
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产品名称

N-(2-Hydroxy) propyl-3-trimethylammonium chitosan chloride, degree of quaternization 50%

description

NMR: Conforms to structure

form

(solid, chunks or fiber)

color

white to off-white

storage temp.

2-8°C

Quality Level

Application

Small molecule and nucleic acid delivery
Tissue engineering
Antibacterial coatings

Features and Benefits

Water soluble
Cationically modified
Naturally derived and biocompatible

General description

Chitosan offers remarkable biological properties; it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.

The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Cationically modified chitosan such as N-(2-Hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) also imparts excellent antibacterial activity and immuno-enhancing characteristics. HTCC also used in gene delivery applications

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Microbiocidal activity of chitosan-N-2-hydroxypropyl trimethyl ammonium chloride
Chi W, et al.
Journal of Applied Polymer Science, 103, 3851-3856 (2007)
Kai Zhao et al.
Vaccines, 9(9) (2021-09-29)
Porcine parvovirus (PPV) is the most important infectious agent causing infertility in pigs, which can be prevented by routine vaccination. Successful vaccination depends on the association with potent adjuvants that can enhance the immunogenicity of antigen and activate the immune
Bo Xiao et al.
Colloids and surfaces. B, Biointerfaces, 91, 168-174 (2011-11-23)
A series of N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) samples with various degrees of quaternization ranging from 12.4 to 43.7% was synthesized. The structures and properties of HTCC were investigated by FT-IR, (1)H NMR, conductometric titration and XRD analysis. It was
Hamid Hamedi et al.
Carbohydrate polymers, 199, 445-460 (2018-08-26)
Advanced development of chitosan hydrogels has led to new drug delivery systems that can release their active ingredients in response to environmental stimuli. This review considers more recent investigation of chitosan hydrogel preparations and the application of these preparations for

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