935166
Hyaluronic acid
acid form, average Mw 25,000
别名:
HA
InChI key
KIUKXJAPPMFGSW-UHFFFAOYSA-N
InChI
1S/C28H44N2O23/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45)
SMILES string
N(C1C(OC(C(C1OC4OC(C(C(C4O)O)O)C(=O)O)O)CO)OC2C(OC(C(C2O)O)OC3C(C(OC(C3O)CO)O)NC(=O)C)C(=O)O)C(=O)C
description
acid form of hylauronic acid
form
powder or chunks (or Fibers)
mol wt
average Mw 25,000
color
white to faint yellow, Faint Brown
application(s)
advanced drug delivery
(Tissue engineering)
storage temp.
2-8°C
Quality Level
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General description
Hyaluronic acid (HA) is a a natural polymer found in many extracellular matrices (ECM). Its biocompatibility, biodegradability, and biomimetic chacteristics make it one of the most advantagous biopolymers for myriad of biomedical applications including drug delivery, tissue engineering, hydrogel development, cosmetics, regenerative medicine and 3D bioprinting.
Unlike other HA products which are typically available in a sodium salt form, HA acid form is soluble in organic solvents such as DMSO. This allows for a larger range of possible chemical modifications and functionalization. For instance, the carboxylic acid of the glucoronic acid can be modified or functionalized with hydrazine end groups.
Unlike other HA products which are typically available in a sodium salt form, HA acid form is soluble in organic solvents such as DMSO. This allows for a larger range of possible chemical modifications and functionalization. For instance, the carboxylic acid of the glucoronic acid can be modified or functionalized with hydrazine end groups.
Application
- Tissue engineering including cartilage tissue engineering, bone tissue engineering, and other musculoskeletal tissues
- Drug delivery and a carrier of small molecules, large molecules, and biomolecules
- Biosensors, films and transdermal microneedles development
- Medical device coatings, wound healing, and cosmetics
Features and Benefits
- The same advantages of HA but in acid form
- Soluble in organic solvents such as DMSO
- Larger range of chemical modifications and functionalization possibilities
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
A mild and straightforward one-pot hyaluronic acid functionalization through termination of poly-(2-alkyl-2-oxazoline)
Madau M, et al.
Polymer, 230, 124059-124059 (2021)
Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory
Gupta R C, et al.
Frontiers in veterinary science, 25, 192-192 (2019)
Thiolated Hyaluronic Acid as Versatile Mucoadhesive Polymer: From the Chemistry Behind to Product Developments-What Are the Capabilities?
Griesser J, et al.
Polymers (Basel, Switzerland), 28, 243-243 (2018)
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