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Merck
CN

F5062

Fmoc-Lys(Me)3-OH Chloride

≥97%, for peptide synthesis

别名:

Fmoc-Lys(Me3Cl)-OH, N-alpha-Fmoc-N-alpha-trimethyl-N-L-lysine · chloride

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关于此项目

经验公式（希尔记法）:
C24H31ClN2O4
化学文摘社编号:
201004-29-7
分子量:
446.97
MDL number:
MFCD00672333
UNSPSC Code:
12352209
NACRES:
NA.26

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产品名称

Fmoc-Lys(Me)3-OH Chloride, ≥97%

SMILES string

Cl.[N+](CCCC[C@H](N=C([O-])OCC1c2c(cccc2)c3c1cccc3)C(=O)O)(C)(C)C

InChI

1S/C24H30N2O4.ClH/c1-26(2,3)15-9-8-14-22(23(27)28)25-24(29)30-16-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21;/h4-7,10-13,21-22H,8-9,14-16H2,1-3H3,(H-,25,27,28,29);1H/t22-;/m0./s1

InChI key

XUJRNPVABVHOAJ-FTBISJDPSA-N

assay

≥97%

form

liquid

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

application(s)

peptide synthesis

functional group

Fmoc

shipped in

dry ice

storage temp.

−20°C

Quality Level

100

相关类别

General description

Fmoc protected N-trimethyl lysine

Application

Fmoc-Lys(Me)3-OH chloride is one of the common N-terminal protected reagents used in the peptide synthesis. Some of the reported examples are:
  • Synthesis of peptide linkers for monoclonal antibody-auristatin F conjugates.
  • Preparation of multifunctional reagents with enhanced ionization properties for the analysis of protein modification in human cells and dynamic profiling of protein lipidation.
  • Sequential peptide ligation to synthesize histone H3 containing a trimethyl lysine residue, with modified tail region.

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000507150
0000507149
0000507149
0000507150
0000282890

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Sequential Peptide Ligation by Combining the Cys?Pro Ester (CPE) and Thioester Methods and Its Application to the Synthesis of Histone H3 Containing a Trimethyl Lysine Residue.
Kawakami T, et al.
Bulletin of the Chemical Society of Japan, 86(6), 690-697 (2013)
Novel peptide linkers for highly potent antibody? auristatin conjugate.
Doronina S O, et al.
Bioconjugate Chemistry, 19(10), 1960-1963 (2008)
Multifunctional Reagents for Quantitative Proteome?Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development.
Broncel M, et al.
Angewandte Chemie (International Edition in English), 54(20), 5948-5951 (2015)

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