T511307
5-乙炔基-2′-脱氧胞苷 (EdC)
AldrichCPR
别名:
2′-Deoxy-5-ethynylcytidine
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关于此项目
经验公式（希尔记法）:
C11H13N3O4
化学文摘社编号:
分子量:
251.24
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
NACRES:
NA.21
产品名称
5-乙炔基-2′-脱氧胞苷 (EdC), AldrichCPR
InChI
1S/C11H13N3O4/c1-2-6-4-14(11(17)13-10(6)12)9-3-7(16)8(5-15)18-9/h1,4,7-9,15-16H,3,5H2,(H2,12,13,17)/t7-,8+,9+/m0/s1
SMILES string
NC1=NC(=O)N(C=C1C#C)[C@H]2C[C@H](O)[C@@H](CO)O2
InChI key
HMJSYXIPNSASJY-DJLDLDEBSA-N
reaction suitability
reaction type: click chemistry
Quality Level
Application
一种用于体内新合成 DNA 代谢标记的相对无毒的 2'-脱氧胞苷类似物。 尤其适用于不希望使用胸苷类似物的情况。
Other Notes
请注意，Sigma-Aldrich 将此产品作为一系列独特化学品的一部分提供给早期研发人员。Sigma-Aldrich 不收集该产品的分析数据。确认产品标识和/或纯度的责任由买方承担。所有销售均为最终销售。
尽管 SIGMA-ALDRICH 的标准条款和条件以及 SIGMA-ALDRICH 和买方之间的协议中包含所有合同条款，但无论是在法律、交易过程、执行过程中的行为、以及贸易或其他方面的使用等过程中，SIGMA-ALDRICH 按“原样”销售此产品并且并对此产品不作任何陈述或担保，包括：(A)适销性担保；(B)特定用途适用性担保；或(C)未侵犯第三方知识产权担保。
尽管 SIGMA-ALDRICH 的标准条款和条件以及 SIGMA-ALDRICH 和买方之间的协议中包含所有合同条款，但无论是在法律、交易过程、执行过程中的行为、以及贸易或其他方面的使用等过程中，SIGMA-ALDRICH 按“原样”销售此产品并且并对此产品不作任何陈述或担保，包括：(A)适销性担保；(B)特定用途适用性担保；或(C)未侵犯第三方知识产权担保。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Lirui Guan et al.
Chembiochem : a European journal of chemical biology, 12(14), 2184-2190 (2011-08-02)
5-Ethynyl-2'-deoxycytidine triphosphate (EdCTP) was synthesized as a probe to be used in conjunction with fluorescent labeling to facilitate the analysis of the in vivo dynamics of DNA-centered processes (DNA replication, repair and cytosine demethylation). Kinetic analysis showed that EdCTP is
Dezhong Qu et al.
Analytical biochemistry, 417(1), 112-121 (2011-06-21)
The labeling of newly synthesized DNA in cells to identify cell proliferation is an important experimental technique. The most accurate methods incorporate [(3)H]thymidine or 5-bromo-2'-deoxyruidine (BrdU) into dividing cells during S phase, which is subsequently detected by autoradiography or immunohistochemistry
Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling.
Ramya Nandakumar et al.
Nature microbiology, 4(4), 701-713 (2019-02-26)
The innate immune system is crucial for eventual control of infections, but may also contribute to pathology. Listeria monocytogenes is an intracellular Gram-positive bacteria and a major cause of food-borne disease. However, important knowledge on the interactions between L. monocytogenes
Yuan-Jhe Chang et al.
Archives of toxicology, 92(8), 2665-2680 (2018-06-27)
Adductomics is expected to be useful in the characterization of the exposome, which is a new paradigm for studying the sum of environmental causes of diseases. DNA adductomics is emerging as a powerful method for detecting DNA adducts, but reliable
Chenglong Sun et al.
Journal of immunology (Baltimore, Md. : 1950), 194(4), 1819-1831 (2015-01-18)
Herpesviruses are DNA viruses harboring the capacity to establish lifelong latent-recurrent infections. There is limited knowledge about viruses targeting the innate DNA-sensing pathway, as well as how the innate system impacts on the latent reservoir of herpesvirus infections. In this
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