A-911
7-氨基氟硝西泮标准液 溶液
1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
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关于此项目
经验公式（希尔记法）:
C16H14FN3O
化学文摘社编号:
分子量:
283.30
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-835-2
MDL number:
InChI key
LTCDLGUFORGHGY-UHFFFAOYSA-N
InChI
1S/C16H14FN3O/c1-20-14-7-6-10(18)8-12(14)16(19-9-15(20)21)11-4-2-3-5-13(11)17/h2-8H,9,18H2,1H3
SMILES string
FC1=CC=CC=C1C2=NCC(N(C)C3=CC=C(N)C=C23)=O
grade
certified reference material
form
liquid
feature
SNAP-N-SPIKE®, SNAP-N-SHOOT®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in acetonitrile
technique(s)
gas chromatography (GC): suitable, liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
Quality Level
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General description
As a major metabolite of flunitrazepam, 7-aminoflunitrazepam is a biomarker for use of the parent drug. Flunitrazepam is an intermediate-acting benzodiazepine, typically used in the treatment of severe insomnia. This certified solution standard is suitable for numerous GC/MS or LC/MS testing applications in forensic analysis, clinical toxicology, urine drug testing, or pain prescription monitoring.
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
35.6 °F - closed cup
flash_point_c
2.0 °C - closed cup
法规信息
危险化学品
此项目有
I Gafni et al.
Journal of clinical psychopharmacology, 23(2), 169-175 (2003-03-18)
Flunitrazepam, a hypnotic benzodiazepine, is widely prescribed around the world for the treatment of insomnia and as a preanesthetic. In vitro studies have shown that the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam is mediated in part by the polymorphic
Chiung-Wei Huang et al.
Journal of chromatography. A, 1110(1-2), 240-244 (2006-02-18)
A sweeping technique, in conjunction with micellar electrokinetic chromatography, for the simultaneous determination of flunitrazepam and its major metabolites, 7-aminoflunitrazepam and N-desmethylflunitrazepam, is described. The optimized conditions for the sweeping and separation were a pH 9.5 buffer, 25mM borate, 50mM
H L Lord et al.
Journal of pharmaceutical and biomedical analysis, 40(3), 769-780 (2005-12-15)
We report on the development of solid phase microextraction probes for drug analysis, prepared with antibodies specific for benzodiazepines covalently immobilized to the surface. In the technique, immobilized antibody probes are exposed to a sample containing the drug for 30
Jeffery Hackett et al.
Forensic science international, 157(2-3), 156-162 (2005-06-16)
The forensic toxicology community has recognized flunitrazepam and its metabolite (7-aminoflunitrazepam) as compounds of concern for several years. In this procedure, the analytes were extracted from whole blood and urine onto single mode solid phase cartridges (butyl) using nitrazepam as
Masaru Terada et al.
Legal medicine (Tokyo, Japan), 5 Suppl 1, S96-S100 (2003-08-26)
A method for the determination of flunitrazepam (FNZ) and 7-aminoflunitrazepam (7-AFNZ) in human serum was developed with ion trap gas chromatography (GC)-tandem mass spectrometry. The 7-AFNZ was derivatizated with 50 microl trifluoroacetic anhydride (TFAA), 60 degrees C-20 min. EI mass
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