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Merck
CN

A-916

7-氨基氯硝西泮标准液 溶液

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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经验公式(希尔记法):
C15H12ClN3O
化学文摘社编号:
分子量:
285.73
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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InChI

1S/C15H12ClN3O/c16-12-4-2-1-3-10(12)15-11-7-9(17)5-6-13(11)19-14(20)8-18-15/h1-7H,8,17H2,(H,19,20)

SMILES string

NC1=CC=C2C(C(C3=C(Cl)C=CC=C3)=NCC(N2)=O)=C1

InChI key

HEFRPWRJTGLSSV-UHFFFAOYSA-N

grade

certified reference material

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

Quality Level

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General description

该认证的Snap-N-Spike®溶液,适合作为法医分析、临床毒理学和尿液药物检测的许多GC/MS或LC/MS应用中校准物或对照品中的起始材料。作为主要代谢产物,7-氨基氯硝西泮可用于监测母体药物氯硝西泮的使用。以Klonopin®和Rivotril出售的氯硝西泮是一种长效苯二氮卓类药物,具有抗焦虑、抗惊厥、肌肉松弛和催眠作用。

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Klonopin is a registered trademark of Hoffmann-La Roche Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

法规信息

危险化学品
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A Negrusz et al.
Journal of analytical toxicology, 24(7), 614-620 (2000-10-24)
Clonazepam (CLO) is an anticonvulsant benzodiazepine approved by the Food and Drug Administration for use in the treatment of seizures. It produces pharmacological effects (depression, amnesia) similar to other compounds from the same therapeutic class, and in combination with alcohol
D R Peng et al.
Pediatric pharmacology (New York, N.Y.), 4(3), 155-159 (1984-01-01)
The N-acetylation of the reduced metabolite of clonazepam 7-amino-clonazepam was studied in cytosolic preparation from human fetal and adult livers. The metabolite formed 7-acetamido-clonazepam was measured with high performance liquid chromatography. A bimodal distribution of the N-acetyltransferase activities was observed
Mitsutoshi Munakata et al.
Epilepsia, 49(10), 1803-1808 (2008-04-26)
A considerable amount of 7-aminoclonazepam (ACZP), a major metabolite of clonazepam (CZP), is present in the brain during CZP treatment, yet the pharmacological properties of ACZP remain unknown. We investigated the effects of ACZP on the GABA(A) receptor-mediated currents (I(GABA))
L W Storhaug et al.
Forensic science international, 222(1-3), e33-e35 (2012-07-24)
Urinary analyses of the metabolite 7-aminoclonazepam (7-AC) can be helpful in monitoring drug abuse and in the context of suspected drug-facilitated sexual assaults (DFSA). Only two studies have reported detection times of 7-AC in urine after a single dose of
Marjorie Chèze et al.
Forensic science international, 145(2-3), 123-130 (2004-09-29)
The number of reports on drug facilitated crimes is increasing these last years. Apart from ethanol and cannabis, benzodiazepines (BZD) and analogs are the most common drugs reported to be used probably due to their amnesic and sedative properties. We

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