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Merck
CN

C-060

Cyclobenzaprine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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经验公式（希尔记法）:
C20H22ClN
化学文摘社编号:
6202-23-9
分子量:
311.85
UNSPSC Code:
41116107
MDL number:
MFCD00079039
NACRES:
NA.24
EC Number:
200-659-6

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产品名称

Cyclobenzaprine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

InChI key

VXEAYBOGHINOKW-UHFFFAOYSA-N

InChI

1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H

SMILES string

Cl.CN(C)CC\C=C1\c2ccccc2C=Cc3ccccc13

grade

certified reference material

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

Quality Level

300

Gene Information

human ... HTR2A(3356), HTR2C(3358)

相关类别

General description

Cyclobenzaprine is a muscle relaxant sold under the trade name Flexeril® to relieve skeletal muscle spasms and associated pain from acute musculoskeletal conditions. This Snap-N-Spike® Reference Solution is suitable for use in LC/MS or GC/MS methods for clinical toxicology, forensic analysis, or urine drug testing applications.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Flexeril is a registered trademark of ALZA Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

存储类别

3 - Flammable liquids

wgk

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

危险化学品
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D R Abernethy et al.
Clinical pharmacology and therapeutics, 90(5), 645-646 (2011-10-21)
The rapid evolution of large biological, pharmacological, and chemical databases has led to optimism that such data resources can be leveraged for prediction of drug action based on molecular descriptors of the drug. Challenges to realize this possibility include organization
Reinhard Reuss et al.
Pharmacology, 84(2), 91-92 (2009-07-11)
The muscle-relaxing 5-HT(2) receptor antagonist cyclobenzaprine is structurally closely related to amitriptyline. It is widely used to treat patients presenting with back pain and fibromyalgia. Very rarely cyclobenzaprine toxicity can result in extrapyramidal symptoms, but occurrence of torticollis has not
Sleep as a window into the world of fibromyalgia syndrome.
Robert Joseph Thomas
The Journal of rheumatology, 38(12), 2499-2500 (2011-12-03)
J Mestres et al.
Clinical pharmacology and therapeutics, 90(5), 662-665 (2011-10-07)
The link between cyclobenzaprine (Flexeril) administration and serotonin syndrome (SS) is subject to debate. Establishing such a connection is difficult because of the limited number of case reports available and the almost complete ignorance of its preclinical pharmacology. In this
Sven Vanneste et al.
International journal of clinical pharmacology and therapeutics, 50(5), 338-344 (2012-05-01)
Tinnitus is defined as an intrinsic sound sensation that cannot be attributed to an external sound source. Currently there are no standardized drug therapies for the treatment of tinnitus. Based on the analogy between pain and tinnitus it is suggested
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