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Merck
CN

D-035

Diltiazem hydrochloride solution

1.0 mg/mL in acetonitrile (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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关于此项目

经验公式（希尔记法）:
C22H27ClN2O4S
化学文摘社编号:
33286-22-5
分子量:
450.98
NACRES:
NA.24
PubChem Substance ID:
329798601
UNSPSC Code:
41116107
EC Number:
200-835-2
MDL number:
MFCD00069252

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InChI key

HDRXZJPWHTXQRI-BHDTVMLSSA-N

InChI

1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1

SMILES string

Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile (as free base)

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

相关类别

General description

A Certified Spiking Solution® produced for use in clinical toxicology, forensic analysis, or pharmaceutical research applications by GC/Ms or LC/MS. Diltiazem is a pharmaceutical drug in the calcium channel blocker class. Diltiazem is prescribed for the treatment of hypertension and heart conditions such as angina pectoris and some types of arrhythmia.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

法规信息

危险化学品
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Toshio Obata et al.
Clinical biochemistry, 46(1-2), 164-166 (2012-09-25)
The interaction between the PKC and oxygen free radicals. The present study examined the effects of lysophosphatidylcholine (LPC), an endogenous amphophilic lipid metabolite, on 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical (()OH) generation in rat striatum. LPC (50 μM) increased ()OH formation
Ronald W Day
Congenital heart disease, 8(1), 71-77 (2012-08-16)
Right heart catheterization is performed in patients with pulmonary arterial hypertension to determine the severity of disease and their pulmonary vascular reactivity. This study sought to determine whether the acute pulmonary vasodilatory effects of diltiazem and oxygen with nitric oxide
[Optimum heart rate - the current goal of cardiovascular therapy. Position statement of the Polish Cardiac Society Working Group on Cardiovascular Drug Therapy].
Jarosław D Kasprzak et al.
Kardiologia polska, 70(10), 1081-1094 (2012-10-20)
Cardiotoxicity with 5-fluorouracil based agents: rechallenge cannot currently be safely advised.
Jonathan R Dalzell et al.
The American journal of cardiology, 111(3), 454-454 (2013-01-16)
Mustafa Kayan et al.
The Journal of membrane biology, 245(12), 833-840 (2012-08-21)
Non-ionic contrast media (CM) can induce tissue kidney injury via activation of phagocytosis and oxidative stress, although the mechanisms of injury via neutrophils are not clear. We investigated the effects of CM on oxidative stress and Ca²⁺ concentrations in serum
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