D-049
N-去甲基氯巴占 溶液
100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
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关于此项目
经验公式（希尔记法）:
C15H11ClN2O2
化学文摘社编号:
分子量:
286.71
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-835-2
MDL number:
InChI key
RRTVVRIFVKKTJK-UHFFFAOYSA-N
InChI
1S/C15H11ClN2O2/c16-10-6-7-12-13(8-10)18(11-4-2-1-3-5-11)15(20)9-14(19)17-12/h1-8H,9H2,(H,17,19)
SMILES string
O=C(C1)N(C2=CC=CC=C2)C3=C(C=CC(Cl)=C3)NC1=O
grade
certified reference material
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
100 μg/mL in acetonitrile
technique(s)
gas chromatography (GC): suitable, liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
Quality Level
General description
认证溶液标准品，用于从法医和法医毒理学分析到尿液药物测试的LC或GC应用。在尿液、血清和血浆中发现的N-去甲基氯巴占是氯巴占的药理活性，主要代谢产物。
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
35.6 °F - closed cup
flash_point_c
2 °C - closed cup
法规信息
监管及禁止进口产品
此项目有
A Guberman et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 17(3), 311-316 (1990-08-01)
Clobazam, a novel benzodiazepine, was used as an add-on agent in 47 adult patients with intractable epilepsy and a variety of seizure types. A greater than 75% reduction in seizure frequency was observed in 42% (18) of the patients and
Mohammadreza Rouini et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 823(2), 167-171 (2005-07-12)
A rapid and specific HPLC method has been developed and validated for simultaneous determination of clobazam, the anticonvulsant agent, and its major metabolite in human plasma. The sample preparation was a liquid-liquid extraction with tuloene yielding almost near 100% recoveries
T Pullar et al.
British journal of clinical pharmacology, 24(6), 793-797 (1987-12-01)
1. The single dose pharmacokinetics of N-desmethylclobazam (NDMC) and clobazam were studied in eight healthy male volunteers. 2. Steady-state pharmacokinetic data are described from four healthy male volunteers and eight epileptic patients taking NDMC. 3. A single 30 mg dose
A H Bardy et al.
Brain & development, 13(3), 174-179 (1991-05-01)
Clobazam was added to the previous antiepileptic drug therapy of 90 children suffering from drug resistant epilepsy. Ten patients became seizure free, although four of these later developed tolerance. Thirty-three patients experienced a decrease in seizure frequency, and 24 of
W Löscher et al.
European journal of pharmacology, 180(2-3), 255-271 (1990-05-16)
The effects of acute and chronic treatment with the 1,5-benzodiazepine, clobazam, were studied on fully kindled amygdaloid seizures in rats. After acute dosing, clobazam significantly reduced all parameters of kindled seizures (seizure severity, seizure duration, duration of amygdalar afterdischarges) at
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