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Merck
CN

G-007

加巴喷丁标准液 CRM 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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经验公式（希尔记法）:
C9H17NO2
化学文摘社编号:
60142-96-3
分子量:
171.24
NACRES:
NA.24
PubChem Substance ID:
329799797
UNSPSC Code:
41116107
MDL number:
MFCD00865286

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产品名称

加巴喷丁标准液 CRM 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

InChI

1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)

SMILES string

NCC1(CCCCC1)CC(O)=O

InChI key

UGJMXCAKCUNAIE-UHFFFAOYSA-N

grade

certified reference material

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

Quality Level

300

Gene Information

human ... CACNA1A(773), CACNA1B(774), CACNA1C(775), CACNA1D(776), CACNA1E(777), CACNA1F(778), CACNA1G(8913), CACNA1H(8912), CACNA1I(8911), CACNA1S(779), CACNA2D1(781), CACNA2D2(9254), CACNA2D3(55799), CACNA2D4(93589), CACNB1(782), CACNB2(783), CACNB3(784), CACNB4(785), CACNG1(786), CACNG2(10369), CACNG3(10368), CACNG4(27092), CACNG5(27091), CACNG6(59285), CACNG7(59284), CACNG8(59283)

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General description

加巴喷丁的商品名为 Neurontin ®、Nupentin 或 Gabarone，是一种抗惊厥药物，主要用于治疗癫痫、纤维肌痛和慢性神经性疼痛。该认证的 Snap-N-Spike ® 参比溶液适用于从法医分析、临床毒理学和疼痛处方监测到尿液药物检测的 GC/MS 或 LC/MS 应用。

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Neurontin is a registered trademark of Warner-Lambert Co.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

危险化学品
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Richard Rauck et al.
Anesthesiology, 119(3), 675-686 (2013-07-10)
Oral gabapentin is approved as an anticonvulsant medication and to treat postherpetic neuralgia. Its nonopioid properties and presumed spinal site of analgesic action made the study on intrathecal gabapentin attractive to establish the minimum effective dose for a later, pivotal
Mark P Jensen et al.
The Clinical journal of pain, 29(9), 770-774 (2013-02-02)
This study evaluated the long-term safety and tolerability of a gastroretentive formulation of gabapentin (G-GR) and its effect on weight gain in postherpetic neuralgia (PHN) patients participating in a 14-week, open-label extension to a 10-week double-blind study. Patients with PHN
Hassan Jalalizadeh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 854(1-2), 43-47 (2007-05-23)
A rapid, sensitive and accurate high-performance liquid chromatographic method with UV detection was developed and validated for the quantification of gabapentin in human plasma. Gabapentin was quantified using pre-column derivatization with 1-fluoro-2,4-dinitrobenzene following protein precipitation of plasma with acetonitrile. Amlodipine
Piotr Czapiński et al.
Current topics in medicinal chemistry, 5(1), 3-14 (2005-01-11)
Gamma-aminobutyric acid (GABA), one of the main inhibitory neurotransmitters in the brain, interacts with three types of receptors for GABA--GABA(A), GABA(B) and GABA(C). GABA(A) receptors, associated with binding sites for benzodiazepines and barbiturates in the form of a receptor complex
Jen-Kun Cheng et al.
Journal of pharmacological sciences, 100(5), 471-486 (2006-02-14)
Gabapentin, a gamma-aminobutyric acid (GABA) analogue anticonvulsant, is also an effective analgesic agent in neuropathic and inflammatory, but not acute, pain systemically and intrathecally. Other clinical indications such as anxiety, bipolar disorder, and hot flashes have also been proposed. Since
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