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安全信息

M-153

Supelco

甲氨蝶呤-D3标准液 CRM 溶液

100 μg/mL in methanol with 0.01N NaOH, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C20H19N8O5D3
CAS号:
432545-63-6
分子量:
457.46
EC 号:
200-659-6
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

100 μg/mL in methanol with 0.01N NaOH

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

pharmaceutical (small molecule)

格式

single component solution

储存温度

−20°C

SMILES字符串

[2H]C([2H])([2H])N(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O

InChI

1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/i1D3

InChI key

FBOZXECLQNJBKD-FIBGUPNXSA-N

相关类别

一般描述

一个适用于通过 LC-MS/MS 对甲氨蝶呤患者血清样品进行治疗性药物监测分析的内标。甲氨蝶呤用于治疗癌症和自身免疫性疾病，是一种抗代谢物和抗叶酸药物，由临床实验室进行监控，以确保患者服用量维持在该药物的治疗范围内。Snap-N-Spike® 解决方案格式可让实验室不需要对氨甲蝶呤等有害物质进行称重操作，显着降低处理剧毒粉末相关的职业暴露危害，并提供在使用前立即掺入所选基质的功能。

应用


  • Application in leukemia research: Methotrexate-D₃ is utilized as an internal standard in LC-MS/MS analysis to monitor the bioavailability and metabolic pathways of thioguanosine and methylthioinosine in children with acute lymphoblastic leukemia, supporting its use in pediatric oncology and pharmacokinetics studies (Han et al., 2022).

  • Enhancement of drug monitoring techniques: Employed in high-throughput MALDI-isotope dilution mass spectrometry, Methotrexate-D₃ allows for the ultrafast and selective quantification of methotrexate in human plasma, proving essential for optimizing therapeutic regimens in cancer treatment (Meesters et al., 2011).

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - Met. Corr. 1 - STOT SE 1

靶器官

Eyes,Central nervous system

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

49.5 °F - closed cup

闪点(°C)

9.7 °C - closed cup

法规信息

危险化学品

分析证书(COA)

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Matthew Jeronimo et al.
Analytical and bioanalytical chemistry, 407(23), 7083-7092 (2015-07-05)
An effective wipe sampling and LC-MS/MS method was developed to simultaneously analyze six commonly administered antineoplastic drugs in stainless steel surface. The analyzed drugs were methotrexate, paclitaxel, cyclophosphamide, 5-fluorouracil, vincristine, and oxaliplatin, a frequently prepared antineoplastic drug that has not

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