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Merck
CN

N-051

Nalbuphine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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经验公式（希尔记法）:
C21H28ClNO4
化学文摘社编号:
23277-43-2
分子量:
393.90
NACRES:
NA.24
UNSPSC Code:
41116107

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产品名称

Nalbuphine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

InChI

1S/C21H27NO4.ClH/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12;/h4-5,12,15-16,19,23-25H,1-3,6-11H2;1H/t15-,16+,19-,20-,21+;/m0./s1

InChI key

YZLZPSJXMWGIFH-BCXQGASESA-N

SMILES string

Cl.O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC6CCC6)c45

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

Quality Level

300

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)

相关类别

General description

A Snap-N-Spike® reference solution applicable for use in urine drug testing, pain prescription monitoring, clinical toxicology, forensic analysis, or pharmaceutical research by LC-MS/MS or GC/MS. Nalbuphine is a semisynthetic opioid analgesic sold under the trade name Nubain®. This painkiller is prescribed for the relief of moderate to severe pain.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Nubain is a registered trademark of Endo Pharmaceuticals Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

监管及禁止进口产品
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Jason S Clark et al.
Veterinary ophthalmology, 14(6), 358-364 (2011-11-05)
To evaluate the effectiveness of topical nalbuphine or oral tramadol in the treatment of corneal pain in dogs. Fourteen male Beagle dogs. Dogs were divided into three treatment groups and sedated with dexmedetomidine (5 μ/kg IV). A 4 mm corneal
David Sanchez-Migallon Guzman et al.
American journal of veterinary research, 72(6), 736-740 (2011-06-02)
To evaluate the antinociceptive effects and duration of action of nalbuphine HCl administered IM on thermal thresholds in Hispaniolan Amazon parrots (Amazona ventralis). 14 healthy adult Hispaniolan Amazon parrots of unknown sex. 3 doses of nalbuphine (12.5, 25, and 50
Juan F De La Mora-González et al.
Middle East journal of anaesthesiology, 21(4), 553-557 (2013-01-19)
Dexmedetomidine has demonstrated to be useful in several clinical fields due to its respiratory safety and cardiovascular stability. We undertook this study to determine its usefulness in plastic surgery. Sixty patients were divided into two parallel groups. A group received
Robert Gear et al.
PloS one, 8(1), e50169-e50169 (2013-01-24)
Nalbuphine, an agonist-antagonist kappa-opioid, produces brief analgesia followed by enhanced pain/hyperalgesia in male postsurgical patients. However, it produces profound analgesia without pain enhancement when co-administration with low dose naloxone. To examine the effect of nalbuphine or nalbuphine plus naloxone on
S Sultana et al.
Drug research, 63(5), 224-227 (2013-03-15)
The interaction of nalbuphine hydrochloride with calf thymus deoxyribonucleic acid was investigated by absorption and fluorescence titration techniques. Hypochromic effect was observed in the absorption spectra of nalbuphine. The fluorescence quenching of nalbuphine by DNA was found to be static
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