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Merck
CN

N-073

硝甲西泮标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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经验公式（希尔记法）:
C16H13N3O3
化学文摘社编号:
2011-67-8
分子量:
295.29
NACRES:
NA.24
PubChem Substance ID:
329818453
UNSPSC Code:
41116107
MDL number:
MFCD00242916

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InChI

1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

SMILES string

CN1C(=O)CN=C(c2ccccc2)c3cc(ccc13)[N+]([O-])=O

InChI key

GWUSZQUVEVMBPI-UHFFFAOYSA-N

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland

Quality Level

300

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

相关类别

General description

尼美西泮以苯二氮卓类药物Erimin的形式销售，用于治疗难以入睡或维持睡眠的患者的压力或短期严重失眠。据报道，东南亚国家（包括泰国、马来西亚、新加坡和香港）向阿拉巴马州和北卡罗来纳州等州报告了滥用案例。尽管在美国没有用于治疗，但该药物以减轻使用甲基苯丙胺或其他兴奋剂后的低迷而闻名。

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

存储类别

3 - Flammable liquids

wgk

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

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N Inotsume et al.
Journal of pharmaceutical sciences, 69(11), 1331-1334 (1980-11-01)
Hydrolytic reactions of nimetazepam and nitrazepam in acidic solutions at body temperature were studied spectrophotometrically. The open-ring compounds produced by hydrolysis were in equilibrium with the corresponding closed-ring compounds (protonated nimetazepam and nitrazepam). Forward-reaction rate constants of both drugs were
[Reduction of nitrazepam and nimetazepam with enteric bacteria].
M Kuroiwa et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 106(5), 414-419 (1986-05-01)
[A case of acute glutethimide poisoning].
M Yao et al.
Masui. The Japanese journal of anesthesiology, 31(9), 1035-1040 (1982-09-01)
H Saito et al.
Research communications in chemical pathology and pharmacology, 52(3), 295-304 (1986-06-01)
In this study, we investigated whether the intensity in the embryotoxicity of benzodiazepines was related to maternal and fetal blood levels and also to their high binding to the fetoplacental structures in rats. Maternal and fetal levels of nitrazepam (NTZ)
T Yotsuyanagi et al.
Clinical and experimental dermatology, 23(3), 113-115 (1998-12-23)
The case is presented of a 34-year-old woman with rhabdomyolysis due to massive intake of nimetazepam, a benzodiazepine hypnotic. On admission, the patient had numerous blisters all over the body. One of the blisters in the gluteal region developed into
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