Merck
CN

S-015

Supelco

西罗莫司 溶液

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

登录to View Organizational & Contract Pricing

Select a Size

Change View
别名:
雷帕霉素
Empirical Formula (Hill Notation):
C51H79NO13
CAS号:
分子量:
914.17
EC 号:
MDL编号:
PubChem化学物质编号:

等级

certified reference material

质量水平

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

manufacturer/tradename

Cerilliant®

浓度

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

格式

single component solution

储存温度

−70°C

SMILES string

CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@H](C)[C@@H]2CC(=O)[C@H](C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC

InChI

1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1

InChI key

QFJCIRLUMZQUOT-HPLJOQBZSA-N

Gene Information

human ... FKBP1A(2280)

比较类似商品

查看完整比较结果

显示差异

1 of 4

此商品
C-093A-094M-136
Sirolimus solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

S-015

西罗莫司 溶液

Cyclosporin A solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

C-093

环孢菌素A 溶液

Ascomycin solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

A-094

Ascomycin solution

Methotrexate solution 1.0 mg/mL in methanol with 0.1N NaOH, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

M-136

甲氨蝶呤,1 X 100MG 溶液

form

liquid

form

liquid

form

liquid

form

liquid

packaging

ampule of 1 mL

packaging

ampule of 1 mL

packaging

ampule of 1 mL

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

manufacturer/tradename

Cerilliant®

manufacturer/tradename

Cerilliant®

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

concentration

1.0 mg/mL in acetonitrile

concentration

1.0 mg/mL in acetonitrile

concentration

1.0 mg/mL in methanol with 0.1N NaOH

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

一般描述

该认证加标溶液® 适用于临床和诊断测试(例如治疗药物监测分析)中的关键定量应用,以确保患者保持在药物窄治疗范围内。 Snap-N-Spike® 规格允许实验室消除西罗莫司等有害物质的称重操作,显著减少与处理急性毒性粉末有关的职业暴露危害,并提供在使用前将其加标到其选择的基质中的能力。

西罗莫司,又称雷帕霉素,属于天然疏水性大环内酯类,被广泛用作免疫抑制药物。除具有免疫抑制活性外,它还具有抗真菌、抗念珠菌、抗肿瘤、抗增殖等作用。西罗莫司是由吸湿链霉菌生产的,用作雷帕霉素(mTOR)抑制剂的哺乳动物靶点。它通过阻断 T 淋巴细胞对细胞因子和抗原的激活和增殖而起作用。

应用

该认证标准溶液(CRM)还可作如下用途:
  • 通过微流体开放界面生物固相微萃取-质谱法(Bio-SPME-MOI-MS/MS)对全血样品中的西罗莫司、他克莫司、依维莫司和环孢素 A 进行多残留分析
  • 开发和验证高效液相色谱-串联质谱法(HPLC-MS/MS)以测定全血样本中的免疫抑制药物环孢素 A、他克莫司、西罗莫司和依维莫司
  • 通过液相色谱-串联质谱法(LC-MS/MS)测定猪全血和肺组织样品中的西罗莫司,使用单步蛋白沉淀法进行样品制备
  • 通过液相色谱-串联质谱法分析移植患者血样中的西罗莫司、环孢素 A、他克莫司和依维莫司通过液相色谱-串联质谱法(LC-MS/MS)测定干燥纸盘基质中西罗莫司、环孢素 A 和依维莫司的含量

特点和优势

  • 完全符合 ISO/IEC 17025 和 ISO 17034 认证
  • 附综合分析证书(CoA),包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
  • 通过实时稳定性研究严格测试,以确保准确性和保质期
  • 使用合格的精密天平进行重量准备,以确保最小不确定性
  • 氩气环境下火焰密封,装入安瓿以便长期保存
  • 提供方便的 DEA 豁免格式,以提高实验室效率

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

FlameExclamation mark

警示用语:

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

35.6 °F - closed cup

闪点(°C)

2 °C - closed cup

法规信息

危险化学品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

在网站页面上,产品编号会附带包装尺寸/数量一起显示(例如:T1503-25G)。请确保 在“产品编号”字段中仅输入产品编号 (示例: T1503).

示例

T1503
货号
-
25G
包装规格/数量

其它示例:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

遇到问题?欢迎随时联系我们技术服务 寻求帮助

批号可以在产品标签上"批“ (Lot或Batch)字后面找到。

Aldrich 产品

  • 如果您查询到的批号为 TO09019TO 等,请输入去除前两位字母的批号:09019TO。

  • 如果您查询到的批号含有填充代码(例如05427ES-021),请输入去除填充代码-021的批号:05427ES。

  • 如果您查询到的批号含有填充代码(例如 STBB0728K9),请输入去除填充代码K9的批号:STBB0728。

未找到您寻找的产品?

部分情况下,可能未在线提供COA。如果搜索不到COA,可在线索取。

索取COA

其他客户在看

Slide 1 of 2

1 of 2

3-Methyladenine autophagy inhibitor

Sigma-Aldrich

M9281

3-甲基腺嘌呤

Posaconazole solution 2.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

P-103

泊沙康唑标准液 溶液

M A Beigh et al.
Journal of biological regulators and homeostatic agents, 27(2), 399-408 (2013-07-09)
S6K1 regulation associates a central role with dynamics of sequential phosphorylations at the hydrophobic motif (T412) and activation loop (T252) of the enzyme, such that the hydrophobic motif phosphorylation supposedly brought about by mTOR- kinase, primes the enzyme for PDK1
Benjamin Albert et al.
The Journal of cell biology, 202(2), 201-210 (2013-07-24)
Chromosomes architecture is viewed as a key component of gene regulation, but principles of chromosomal folding remain elusive. Here we used high-throughput live cell microscopy to characterize the conformation and dynamics of the longest chromosome of Saccharomyces cerevisiae (XII). Chromosome
Combination of rapamycin and imatinib in treating refractory chronic myeloid leukemia myeloid blast crisis:a case report(025B3;).
Jing Xie et al.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 28(2), 127-128 (2013-06-29)
Young Joo Shin et al.
Investigative ophthalmology & visual science, 54(7), 4452-4458 (2013-05-30)
To investigate the protective effect of rapamycin against alkali burn-induced corneal damage in mice. BALB/c mice were treated with 0.1 N NaOH to the cornea for 30 seconds. Corneal neovascularization and opacity were clinically evaluated at 1, 2, and 4
Elisabeth Brunner et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 22(3), 355-359 (2013-07-06)
In lung transplantation, acute rejection episodes increase the risk of chronic rejection. Therefore treatment of acute rejection needs to be optimized for better long-term outcome of lung-transplantation and patient survival. The aim was to verify whether an inhibitor of the

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门