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Merck
CN

T-050

Temazepam glucuronide lithium salt solution

100 μg/mL in methanol (as free carboxylate), ampule of 1 mL, certified reference material, Cerilliant®

别名:

Temazepam Glucuronide Solution

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关于此项目

经验公式（希尔记法）:
C22H20ClLiN2O8
分子量:
482.80
UNSPSC Code:
41116107
NACRES:
NA.24
EC Number:
200-659-6
MDL number:
MFCD29918103

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产品名称

Temazepam glucuronide lithium salt solution, 100 μg/mL in methanol (as free carboxylate), ampule of 1 mL, certified reference material, Cerilliant®

InChI key

RQHXRNLYSZXQKI-NMJPLRNWSA-M

InChI

1S/C22H21ClN2O8.Li/c1-25-13-8-7-11(23)9-12(13)14(10-5-3-2-4-6-10)24-19(20(25)29)33-22-17(28)15(26)16(27)18(32-22)21(30)31;/h2-9,15-19,22,26-28H,1H3,(H,30,31);/q;+1/p-1/t15-,16-,17+,18-,19?,22-;/m0./s1

SMILES string

[Li+].CN1C(=O)C(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C([O-])=O)N=C(c3ccccc3)c4cc(Cl)ccc14

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland)
kontrollierte Droge in Deutschland

Quality Level

300

concentration

100 μg/mL in methanol (as free carboxylate)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

相关类别

General description

The major urinary and blood metabolite of temazepam, an intermediate-acting 3-hydroxy benzodiazepine prescribed for the short-term treatment of sleeplessness in patients with difficulties remaining asleep. This new Certified Reference Standard is suitable for a variety of LCMS and GCMS applications, including forensic and forensic toxicology analysis, urine drug testing, and hydrolysis controls.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

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G W Kunsman et al.
Journal of chromatography, 568(2), 427-436 (1991-08-23)
A rapid and sensitive method for extracting temazepam from human serum and urine is presented. Free temazepam is extracted from plasma and urine samples using n-butyl chloride with nitrazepam as the internal standard. Temazepam glucuronide is analyzed as free temazepam
Commentary on: Dou C, Bournique J, Zinda M, Gnezda M, Nally A, Salamone S. Comparison of rates of hydrolysis of lorazepam-glucuronide, oxazepam-glucuronide and temazepam-glucuronide catalyzed by E. coli beta-glucuronidase using the on-line benzodiazepine screening immunoassay on the Roche/Hitachi 917 analyzer.
Carol L O'Neal et al.
Journal of forensic sciences, 47(2), 427-428 (2002-03-23)

实验方案

UHPLC/MS for Drug Detection in Urine

Optimize β-glucuronidase hydrolysis for glucuronide metabolite analysis considering factors like time, temperature, pH, and enzyme concentration.

使用UHPLC/MS（TOF）检测不同酶水解条件处理的尿液中药物和代谢物

为了使用β-葡糖醛酸酶优化水解，必须对每种待分析的葡糖苷酸代谢物进行某些因素的评估，例如孵育时间、温度、水解pH、酶源和酶浓度。

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