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Merck
CN

T-068

Tilidine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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经验公式（希尔记法）:
C17H23NO2 · HCl
化学文摘社编号:
27107-79-5
分子量:
309.83
NACRES:
NA.24
PubChem Substance ID:
329826611
UNSPSC Code:
41116107
EC Number:
200-659-6
MDL number:
MFCD01735084

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InChI key

MUWDJVKYGSDUSH-KALLACGZSA-N

InChI

1S/C17H23NO2.ClH/c1-4-20-16(19)17(14-10-6-5-7-11-14)13-9-8-12-15(17)18(2)3;/h5-8,10-12,15H,4,9,13H2,1-3H3;1H/t15-,17+;/m1./s1

SMILES string

Cl.CCOC(=O)[C@@]1(CCC=C[C@H]1N(C)C)c2ccccc2

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal), kontrollierte Droge in Deutschland

Quality Level

300

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

相关类别

General description

Tilidine is a synthetic opioid analgesic used mainly in Germany, Switzerland and Belgium for treatment of moderate to severe pain, both acute and chronic. While tilidine is considered a moderately-potent opioid, its active metabolite nortilidine possesses analgesic effects roughly equivalent to that of morphine.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

存储类别

3 - Flammable liquids

wgk

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

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Barbara Grün et al.
British journal of clinical pharmacology, 74(5), 854-863 (2012-03-03)
The analgesic activity of tilidine is mediated by its active metabolite, nortilidine, which easily penetrates the blood-brain barrier and binds to the µ-opioid receptor as a potent agonist. Tilidine undergoes an extensive first-pass metabolism, which has been suggested to be
[Low-dose strong opioid (LDSO)--treatment of pain in osteoarthritis].
W W Bolten et al.
MMW Fortschritte der Medizin, 150(51-52), 41-41 (2009-01-22)
Paul J Fudala et al.
Drug and alcohol dependence, 83 Suppl 1, S40-S47 (2006-03-28)
Non-medical abuse of prescription opioid medications is not a new phenomenon, but such use has been increasing in recent years. Various methods have been used and continue to be developed in an effort to limit diversion and abuse of opioid
[The chronic pain patient: assuring long-term success].
Thomas Nolte
Krankenpflege Journal, 43(7-10), 203-203 (2006-03-07)
Christoph Köhler et al.
Analytical and bioanalytical chemistry, 400(1), 17-23 (2010-12-09)
The opioid tilidine is a prodrug which is hepatically metabolized to active nortilidine and bisnortilidine. Due to the increasing abuse of tilidine by drug users and the lack of a specific immunoassay, we developed an analytical method for the quantification
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