产品名称
抗乙酰组蛋白 H4（Lys5）抗体，兔单克隆, culture supernatant, Upstate®
biological source
rabbit
antibody form
culture supernatant
antibody product type
primary antibodies
clone
monoclonal
species reactivity
vertebrates, human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
acetylation (Lys5)
Quality Level
Gene Information
human ... H4C1(8359)
相关类别
Physical form
100 μL兔单克隆IgG细胞培养物上清液，溶于0.1%叠氮化钠。
Preparation Note
自运送之日起在-20°C下保存2年
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Analysis Note
已通过免疫印迹进行常规评估。
Application
使用兔抗乙酰组蛋白H4（Lys5）抗体检测乙酰组蛋白（Lys5），经验证可用于WB。
研究子类别
组蛋白
组蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
在Lys5上乙酰化时识别组蛋白H4。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
11kDa
Immunogen
对应于组蛋白H4的肽，包含Lys5被乙酰化的序列[GRG-AcK-GGK]。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Haipeng Guan et al.
Nature, 620(7974), 669-675 (2023-07-20)
Context-dependent dynamic histone modifications constitute a key epigenetic mechanism in gene regulation1-4. The Rpd3 small (Rpd3S) complex recognizes histone H3 trimethylation on lysine 36 (H3K36me3) and deacetylates histones H3 and H4 at multiple sites across transcribed regions5-7. Here we solved
Zengxuan An et al.
The Plant journal : for cell and molecular biology, 103(3), 1010-1024 (2020-04-24)
Histones are highly basic proteins involved in packaging DNA into chromatin, and histone modifications are fundamental in epigenetic regulation in eukaryotes. Among the numerous chromatin modifiers identified in Arabidopsis (Arabidopsis thaliana), MORF-RELATED GENE (MRG)1 and MRG2 have redundant functions in
S Ono et al.
Journal of experimental & clinical cancer research : CR, 21(3), 377-382 (2002-10-19)
Acetylation of core histones is closely linked to transcriptional activation of various genes. The acetylation levels of nucleosomal histones can be modified through a balance of histone acetyltransferases and deacetylases. To elucidate the role of histone acetylation in human gastric
RSC exploits histone acetylation to abrogate the nucleosomal block to RNA polymerase II elongation.
Carey, Michael, et al.
Molecular Cell, 24, 481-487 (2006)
Sepehr Ehsani et al.
Journal of molecular biology, 422(4), 556-574 (2012-06-13)
We recently documented the co-purification of members of the LIV-1 subfamily of ZIP (Zrt-, Irt-like Protein) zinc transporters (LZTs) with the cellular prion protein (PrP(C)) and, subsequently, established that the prion gene family descended from an ancestral LZT gene. Here
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