04-299
抗磷酸化胰岛素受体（Tyr 1150/1151）抗体（克隆10C3）
clone 10C3, Upstate®, from mouse
别名:
INSR
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
10C3, monoclonal
Species reactivity:
human
Application:
WB, activity assay
Citations:
9
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
10C3, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pTyr1150/pTyr1151)
Quality Level
Gene Information
human ... INSR(3643)
General description
97kda
Immunogen
KLH偶联的合成肽，对应于磷酸化胰岛素受体上酪氨酸1150/1151周围的氨基酸。
Application
使用经验证可用于EA & WB的该抗磷酸化胰岛素受体（Tyr 1150/1151）抗体（克隆10C3）检测磷酸化胰岛素受体（Tyr 1150/1151）。
Biochem/physiol Actions
可识别胰岛素受体中酪氨酸1150/1151上的磷酸化结构域。
Physical form
形式：纯化
溶于含0.09%叠氮化钠、PEG、蔗糖和50%甘油的1 mL PBS。
Analysis Note
对照
包括过钒酸盐处理的HEK293 裂解液作为阳性对照
包括过钒酸盐处理的HEK293 裂解液作为阳性对照
已通过免疫印迹进行常规评估。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
Natalie N Rizk et al.
Fertility and sterility, 86(4 Suppl), 1217-1222 (2006-09-12)
To determine whether the insulin receptor (IR), insulin-like growth factor-I receptor (IGF-IR), and IGF-I are expressed differentially in fibroblasts isolated from normal peritoneal and adhesion tissue before and after 24-hour treatment with increasing glucose concentrations. Prospective experimental study. University medical
Qiu-yan Wang et al.
The FEBS journal, 274(2), 526-538 (2007-01-19)
Two H7721 human hepatocarcinoma cell lines showing moderate and high expression of alpha1,3-fucosyltransferase (FucT)-VII cDNA were established and designated FucTVII-M and FucTVII-H, respectively. In alpha1,3-FucT-VII-transfected cells, expression of insulin receptor (InR) alpha- and beta subunits and epidermal growth factor receptor
Amer Youssef et al.
Endocrinology, 157(3), 1163-1174 (2016-01-14)
Placental mesenchymal stem cells (PMSCs) are readily available multipotent stem cells for potential use in regenerative therapies. For this purpose, PMSCs must be maintained in culture conditions that mimic the in vivo microenvironment. IGFs (IGF-1 and IGF-2) and oxygen tension
Adrián Martín-Segura et al.
Aging cell, 18(3), e12932-e12932 (2019-03-19)
In the brain, insulin plays an important role in cognitive processes. During aging, these faculties decline, as does insulin signaling. The mechanism behind this last phenomenon is unclear. In recent studies, we reported that the mild and gradual loss of
Atsumi Tsuji-Hosokawa et al.
Pediatric diabetes, 18(8), 917-924 (2017-02-10)
Defects of the insulin receptor gene ( INSR ) cause wide spectra of congenital insulin resistance. Monoallelic defects result in milder insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN, type A). Whereas, leprechaunism (Donahue syndrome), the most severe condition with lethality
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