04-469
抗SREBP1抗体，克隆2121
clone 2121, Upstate®, from mouse
别名:
SREBF1, sterol regulatory element binding transcription factor 1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
2121, monoclonal
Application:
WB
Citations:
12
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
2121, monoclonal
species reactivity
human
packaging
antibody small pack of 25 μL
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SREBF1(6720)
General description
126kda
Immunogen
包含氨基酸301-407的重组His标签人SREBP-1a蛋白。
Application
抗SREBP1抗体，克隆2121，是一种小鼠单克隆抗体，可用于检测SREBP1（也被称为固醇调节元件结合转录因子1 &），其已在WB中进行验证。
Biochem/physiol Actions
可与SREBP的碱性螺旋-环-螺旋亮氨酸拉链（bHLH-ZIP）发生反应。
Physical form
100 μL（1 mg/mL）蛋白A纯化的小鼠单克隆IgG1，溶于含0.1％叠氮化钠的PBS中。
形式：纯化
Preparation Note
自收到之日起在-20°C可稳定保存2年。 第一次融化后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。 分装到微量离心管中，并储存于 -20°C。 避免反复冻融循环，以免损坏 IgG 和影响产品性能。 注意： 冷藏室温度变化至低于-20°C时可能导致-含甘油的溶液在储存过程中冻结。
Analysis Note
已通过免疫印迹进行常规评估。
Other Notes
请参考特定批次的数据表。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Tanel Punga et al.
The Journal of biological chemistry, 281(35), 25278-25286 (2006-07-11)
Members of the sterol regulatory element-binding protein (SREBP) family of transcription factors control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation. The transcription factor SREBP1 is degraded by the ubiquitin-proteasome system following phosphorylation of Thr426 and Ser430
Shreetama Bandyopadhayaya et al.
Journal of biochemical and molecular toxicology, 35(4), e22693-e22693 (2021-01-05)
N-acyl dopamines (NADAs) are bioactive lipids of the endovanilloid family with known cytotoxicity for the cancer cells; however, the available data on the participation of the endovanilloids in epithelial-mesenchymal transition (EMT) and cancer stemness are controversial. This study unveils the
X Wang et al.
The Journal of biological chemistry, 268(19), 14497-14504 (1993-07-05)
This paper describes the purification and characterization of a sterol regulatory element binding protein (SREBP) that recognizes the SRE-1 sequence in the 5' flanking region of the gene for the low density lipoprotein (LDL) receptor. The protein was purified more
Amy K Walker et al.
Genes & development, 24(13), 1403-1417 (2010-07-03)
The sterol regulatory element-binding protein (SREBP) transcription factor family is a critical regulator of lipid and sterol homeostasis in eukaryotes. In mammals, SREBPs are highly active in the fed state to promote the expression of lipogenic and cholesterogenic genes and
Lee-Ann Van de Velde et al.
The Journal of biological chemistry, 292(1), 15-30 (2016-12-03)
Modulation of T cell proliferation and function by immunoregulatory myeloid cells are an essential means of preventing self-reactivity and restoring tissue homeostasis. Consumption of amino acids such as arginine and tryptophan by immunoregulatory macrophages is one pathway that suppresses local
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