04-469
抗SREBP1抗体，克隆2121
clone 2121, Upstate®, from mouse
别名:
SREBF1, sterol regulatory element binding transcription factor 1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
2121, monoclonal
Application:
western blot
Species reactivity:
human
Citations:
12
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
抗SREBP1抗体，克隆2121, clone 2121, Upstate®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
2121, monoclonal
species reactivity
human
packaging
antibody small pack of 25 μL
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SREBF1(6720)
Analysis Note
已通过免疫印迹进行常规评估。
Application
抗SREBP1抗体，克隆2121，是一种小鼠单克隆抗体，可用于检测SREBP1（也被称为固醇调节元件结合转录因子1 &），其已在WB中进行验证。
Biochem/physiol Actions
可与SREBP的碱性螺旋-环-螺旋亮氨酸拉链（bHLH-ZIP）发生反应。
General description
126kda
Immunogen
包含氨基酸301-407的重组His标签人SREBP-1a蛋白。
Other Notes
请参考特定批次的数据表。
Physical form
100 μL（1 mg/mL）蛋白A纯化的小鼠单克隆IgG1，溶于含0.1％叠氮化钠的PBS中。
形式：纯化
Preparation Note
自收到之日起在-20°C可稳定保存2年。 第一次融化后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。 分装到微量离心管中，并储存于 -20°C。 避免反复冻融循环，以免损坏 IgG 和影响产品性能。 注意： 冷藏室温度变化至低于-20°C时可能导致-含甘油的溶液在储存过程中冻结。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Tanel Punga et al.
The Journal of biological chemistry, 281(35), 25278-25286 (2006-07-11)
Members of the sterol regulatory element-binding protein (SREBP) family of transcription factors control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation. The transcription factor SREBP1 is degraded by the ubiquitin-proteasome system following phosphorylation of Thr426 and Ser430
X Wang et al.
The Journal of biological chemistry, 268(19), 14497-14504 (1993-07-05)
This paper describes the purification and characterization of a sterol regulatory element binding protein (SREBP) that recognizes the SRE-1 sequence in the 5' flanking region of the gene for the low density lipoprotein (LDL) receptor. The protein was purified more
Shreetama Bandyopadhayaya et al.
Journal of biochemical and molecular toxicology, 35(4), e22693-e22693 (2021-01-05)
N-acyl dopamines (NADAs) are bioactive lipids of the endovanilloid family with known cytotoxicity for the cancer cells; however, the available data on the participation of the endovanilloids in epithelial-mesenchymal transition (EMT) and cancer stemness are controversial. This study unveils the
Amy K Walker et al.
Genes & development, 24(13), 1403-1417 (2010-07-03)
The sterol regulatory element-binding protein (SREBP) transcription factor family is a critical regulator of lipid and sterol homeostasis in eukaryotes. In mammals, SREBPs are highly active in the fed state to promote the expression of lipogenic and cholesterogenic genes and
Lee-Ann Van de Velde et al.
The Journal of biological chemistry, 292(1), 15-30 (2016-12-03)
Modulation of T cell proliferation and function by immunoregulatory myeloid cells are an essential means of preventing self-reactivity and restoring tissue homeostasis. Consumption of amino acids such as arginine and tryptophan by immunoregulatory macrophages is one pathway that suppresses local
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