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Merck
CN

05-117

抗-FGF-2/碱性FGF（中和）抗体，克隆bFM-1

clone bFM-1, Upstate®, from mouse

别名:

GSK3β, GSK3B, 糖原合成酶激酶3β, 糖原合酶激酶3β

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
bFM-1, monoclonal
Application:
neutralization
radioimmunoassay
Species reactivity:
human, mouse, bovine, rat
Citations:
67
Technique(s):
neutralization: suitable
radioimmunoassay: suitable
Uniprot accession no.:
P09038

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产品名称

抗-FGF-2/碱性FGF（中和）抗体，克隆bFM-1, clone bFM-1, Upstate®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

bFM-1, monoclonal

form

liquid

mol wt

17.5 kDa

species reactivity

human, mouse, bovine, rat

manufacturer/tradename

Upstate®

technique(s)

neutralization: suitable
radioimmunoassay: suitable

isotype

IgG1κ

suitability

not suitable for Western blot

NCBI accession no.

NM_002006.3

UniProt accession no.

P09038

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... FGF2(2247)
mouse ... Fgf2(281161), Fgf2(14173)
rat ... Fgf2(54250)

相关类别

Analysis Note

通过中和大于50%的FGF-2/bFGF模拟的FBHE细胞生长进行常规评估。

bFGF活性测定的中和：
2.5 µg/mL的该批次抗体中和了用5 ng/mL FGF-2/bFGF模拟的FBHE细胞超过40%的生长。

Application

抗FGF-2/碱性FGF（中和）抗体，克隆bFM-1已用于：

  • FGF2中和测定（6或12µg/mL）
  • 体外成管测定（1000 ng/mL）
  • 免疫标记（1:200）
Anti-FGF-2/basic FGF (neutralizing), clone bFM-1, Cat. No. 05-117, is a mouse monoclonal antibody that detects Basic fibroblast growth factor (bFGF) and is tested for use in ELISA, Western Blotting, Radioimmunoassay, and Neutralizing.

Biochem/physiol Actions

该抗体对牛、人、大鼠和小鼠来源的非变性形式FGF-2/碱性FGF具有高度特异性。 不与牛酸性FGF发生交叉反应。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

17.5 kDa
成纤维细胞生长因子2（FGF-2）属于肝素结合生长因子家族。它位于中胚层和神经外胚层起源的细胞以及一些肿瘤细胞中。FGF-2有四种亚型。它由四个半胱氨酸残基、多个碱性残基和两个活性位点组成。FGF-2蛋白质是由十二个反平行β折叠片组成的三角金字塔结果。FGF-2染色体位于染色体4q28.1。

研究领域：癌症

Immunogen

表位：氨基酸5-24

Other Notes

浓度：请参考批次特异性浓缩物的分析证书。

Physical form

TBS中纯化的小鼠单克隆抗体IgG1κ。使用小鼠IgG作为标准品，通过Bradford微量滴定法测定蛋白质。 冷冻溶液。
形式：纯化

Preparation Note

自收到之日起在-20ºC可稳定保存1年。避免反复冻融。为了最大程度地回收产品，需在融化后和取下盖子之前将原始样品管进行离心。

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne
Petridis C, et al.
Nature Communications, 5075, 9(1)-9(1) (2018)
A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation.
Jaime Gutierrez,Enrique Brandan
Molecular and cellular biology null
T Korff et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15(2), 447-457 (2001-02-07)
Paracrine interactions between endothelial cells (EC) and mural cells act as critical regulators of vessel wall assembly, vessel maturation and define a plasticity window for vascular remodeling. The present study was aimed at studying blood vessel maturation processes in a
Madalyn Hafenbreidel et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(13), 2907-2915 (2015-05-23)
Drug exposure results in structural and functional changes in brain regions that regulate reward and these changes may underlie the persistence of compulsive drug seeking and relapse. Neurotrophic factors, such as basic fibroblast growth factor (bFGF or FGF2), are necessary
Vigdis Sørensen et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 28(5), 504-514 (2006-04-15)
Regulation of the subcellular localization of certain proteins is a mechanism for the regulation of their biological activities. FGF-2 can be produced as distinct isoforms by alternative initiation of translation on a single mRNA and the isoforms are differently sorted
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