05-1424
抗内皮糖蛋白抗体，克隆P3D1
clone P3D1, from mouse
别名:
CD105, Ancillary TGF-beta Receptor
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
P3D1, monoclonal
Application:
ELISA
flow cytometry
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
Species reactivity:
mouse, human
Citations:
10
Technique(s):
ELISA: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗内皮糖蛋白抗体，克隆P3D1, clone P3D1, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
P3D1, monoclonal
species reactivity
mouse, human
species reactivity (predicted by homology)
rat
technique(s)
ELISA: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ENG(2022)
mouse ... Eng(13805)
rat ... Eng(497010)
Other Notes
替代：MAB2152
浓度：请参考批次特异性浓缩物的分析证书。
Analysis Note
对照
Jurkat细胞裂解液
Jurkat细胞裂解液
通过蛋白质印迹在Jurkat裂解液中进行了常规评估。
蛋白质印迹分析： 该批次以1：500的稀释度在10 μg Jurkat裂解液中检测到ENDOGLIN。
蛋白质印迹分析： 该批次以1：500的稀释度在10 μg Jurkat裂解液中检测到ENDOGLIN。
Application
免疫组化：用于丙酮或多聚甲醛固定的组织。
ELISA： 先前批次的抗体用于ELISA。
免疫沉淀： 先前批次的抗体用于IP。
免疫细胞化学： 先前批次的抗体用于IC。
流式细胞术： 先前批次的抗体用于FC。
终端用户需自行确定最佳的工作稀释度。
ELISA： 先前批次的抗体用于ELISA。
免疫沉淀： 先前批次的抗体用于IP。
免疫细胞化学： 先前批次的抗体用于IC。
流式细胞术： 先前批次的抗体用于FC。
终端用户需自行确定最佳的工作稀释度。
抗内皮糖蛋白抗体，克隆P3D1是抗内皮糖蛋白的抗体，用于WB，IH，IC，IP，FC，ELISA。
研究子范畴
生长因子 & 受体
生长因子 & 受体
研究类别
信号传导
信号传导
Biochem/physiol Actions
与人内皮糖蛋白反应。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
~71 kDa
内皮糖蛋白是由95 kDa亚基组成的同型二聚体整合膜糖蛋白。内皮糖蛋白是TGF-B受体系统的一个组分，其作为辅助受体起作用，影响转化生长因子β（TGF-β）家族配体与信号受体的结合。内皮糖蛋白以高亲和力结合TGF-B1和TGF-B3，但未结合TGF-b2。内皮糖蛋白由胎盘的血管内皮细胞和合体滋养层细胞表达，而间质成纤维细胞则弱表达。它也由U937细胞和活化的巨噬细胞表达。内皮糖蛋白的表达在经历血管生成的组织（例如在肿瘤中）或在伤口愈合或皮肤炎症的情况下在活化的内皮上上调。
Immunogen
人静息脐静脉内皮细胞。
Physical form
形式：纯化
纯化
纯化小鼠单克隆IgG2a，溶于0.02 M磷酸盐缓冲液、0.25 M氯化钠、0.1%叠氮化钠，pH 7.6
Preparation Note
自收到之日起，在2-8°C下可稳定保存1年。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Nicole M Valenzuela et al.
Journal of immunology (Baltimore, Md. : 1950), 190(12), 6635-6650 (2013-05-22)
Ab-mediated rejection (AMR) of solid organ transplants is characterized by intragraft macrophages. It is incompletely understood how donor-specific Ab binding to graft endothelium promotes monocyte adhesion, and what, if any, contribution is made by the Fc region of the Ab.
Snail1 controls TGF-? responsiveness and differentiation of mesenchymal stem cells.
Batlle, R, et al.
Oncogene (2012)
Lulwah Aldabbous et al.
Arteriosclerosis, thrombosis, and vascular biology, 36(10), 2078-2087 (2016-07-30)
Inflammation and dysregulated angiogenesis are features of endothelial dysfunction in pulmonary hypertension. Neutrophil extracellular traps (NETs), produced by dying neutrophils, contribute to pathogenesis of numerous vascular disorders but their role in pulmonary hypertension has not been studied. We sought evidence
Takuya Tokunaga et al.
The American journal of sports medicine, 43(10), 2411-2422 (2015-08-28)
Fibroblast growth factor (FGF)-2 has the potential to enhance tendon-to-bone healing after rotator cuff (RC) injury. FGF-2 stimulates tenogenic differentiation of progenitors to improve the biomechanical strength and histological appearance of repaired RCs in rats. Controlled laboratory study. Adult male
Yohei Nishida et al.
International journal of molecular sciences, 21(15) (2020-08-06)
The stromal-cell-derived factor-1α (SDF-1) is well-known for playing important roles in the regeneration of tissue by enhancing cell migration. However, the effect of SDF-1 in meniscal healing remains unknown. The purpose of this study is to investigate the effects of
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