05-718
抗-PML抗体（克隆36.1-104）
clone 36.1-104, Upstate®, from mouse
别名:
Anti-MYL, Anti-PP8675, Anti-RNF71, Anti-TRIM19
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
36.1-104, monoclonal
Application:
ICC, WB
Species reactivity:
mouse
Citations:
34
Technique(s):
immunocytochemistry: suitable, western blot: suitable
Uniprot accession no.:
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
36.1-104, monoclonal
species reactivity
mouse
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PML(5371)
Analysis Note
对照
MEF1 细胞裂解液
MEF1 细胞裂解液
已通过免疫印迹对小鼠胚胎成纤维细胞（MEF1）的RIPA裂解液进行常规评估
Application
使用经证明可在ICC & WB中起作用的抗-PML 抗体（克隆36.1-104，小鼠单克隆抗体）检测PML，也称早幼粒细胞白血病蛋白。
研究子类别
转录因子
转录因子
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
可识别PML。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
90-106 kDa
早幼粒细胞白血病基因产物（PML）是一种具有生长抑制特性的核蛋白，最初被鉴定为急性早幼粒细胞白血病的PML-维甲酸受体α（RAR α）融合蛋白。 PML 位于不同核结构即核体的内部，该结构受PML-RAR α表达的破坏。
Immunogen
6His 融合蛋白，对应于小鼠PML（早幼粒细胞白血病蛋白）
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
蛋白G纯化
蛋白G纯化的免疫球蛋白，溶于0.1M Tris-甘氨酸（pH 7.4）、0.15M NaCl和0.05％叠氮化钠防腐中。
Preparation Note
自收到之日起在-20°C可稳定保存2年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Gerdine J Stout et al.
Cancer research, 73(6), 1844-1854 (2013-01-05)
Xeroderma pigmentosum (XP), a UV-sensitivity syndrome characterized by skin hyperpigmentation, premature aging, and increased skin cancer, is caused by defects in the nucleotide excision repair (NER) pathway. XP shares phenotypical characteristics with telomere-associated diseases like Dyskeratosis congenita and mouse models
Abrar Ahmed et al.
Scientific reports, 7, 44539-44539 (2017-03-21)
Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation. We demonstrate that PML promotes TNFα-induced transcriptional responses by promoting
Alyssa L Kennedy et al.
Cell division, 5, 16-16 (2010-06-24)
Cellular senescence is a permanent growth arrest that occurs in response to cellular stressors, such as telomere shortening or activation of oncogenes. Although the process of senescence growth arrest is somewhat conserved between mouse and human cells, there are some
SUMO-1-dependent allosteric regulation of thymine DNA glycosylase alters subnuclear localization and CBP/p300 recruitment.
Mohan, RD; Rao, A; Gagliardi, J; Tini, M
Molecular and cellular biology null
Evgenij Evdokimov et al.
Journal of cell science, 121(Pt 24), 4106-4113 (2008-11-27)
Conjugation of the small ubiquitin-like modifier (SUMO) to target proteins regulates numerous biological processes and has been implicated in tumorigenesis and metastasis. The three SUMO isoforms in vertebrates, SUMO1 and the highly similar SUMO2 and SUMO3, can be conjugated to
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