06-503-I
抗-Caspase 1抗体
from rabbit, purified by affinity chromatography
别名:
Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45
产品名称
抗-Caspase 1抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CASP1(834)
Analysis Note
通过蛋白质印迹对THP-1细胞裂解液进行了评估。
蛋白质印迹分析：5 µg/mL的该抗体在10 µg THP-1细胞裂解液中检测到半胱天冬酶1。
蛋白质印迹分析：5 µg/mL的该抗体在10 µg THP-1细胞裂解液中检测到半胱天冬酶1。
Application
免疫组化分析：代表批次的1：1,000稀释液在人脾脏组织中检测到半胱天冬酶1。此外，代表批次的1:4,000稀释液在人结肠组织中检测到半胱天冬酶1。
抗半胱天冬酶1抗体是一种高度特异性的兔多克隆抗体，靶向半胱天冬酶1 & 已通过蛋白质印迹&IHC（石蜡）进行测试。
研究子类别
半胱天冬酶
半胱天冬酶
Biochem/physiol Actions
其他同源性：小鼠、大鼠、犬、猪和猫。（92%序列同源性）。
该抗体可识别半胱天冬酶1的p20亚基。由于92%的序列同源性，该抗体可与半胱天冬酶5发生交叉反应。此外，该抗体可识别还原型人半胱天冬酶1亚型的P45酶原（~45 kDa）和p20亚基（~20 kDa）。
General description
半胱天冬酶-1，也称为IL-1β转化酶（ICE），是一种酶，可裂解炎性细胞因子IL-1β和IL-18，从而释放成熟的活性肽。半胱天冬酶-1对于防御病原体很重要，并且它也参与细胞凋亡的诱导。来自半胱天冬酶-1缺陷小鼠的胸腺细胞对Fas介导的细胞凋亡具有抗性，并且半胱天冬酶-1与秀丽隐杆线虫的细胞死亡基因CED-3相似。半胱天冬酶-1是由两个反平行异二聚体组成的异四聚体，每个异二聚体由20 kDa（p20）和10 kDa（p10）亚基形成。该酶具有Tyr-Val-Ala-Asp(YVAD)的优选切割位点。半胱天冬酶-1在脾脏和肺中高表达，而在大脑中则不存在。
观测值〜45 kDa。已知存在10-45 kDa之间的五个亚型。该抗体可识别还原的人半胱天冬酶1亚型的P45酶原（~45 kDa）和p20亚基（~20 kDa）。
Immunogen
与人半胱天冬酶1的p20亚基相对应的KLH偶联的线性肽。
表位：p20亚基
Other Notes
替代：06-503
浓度：请参考批次特异性浓缩物的分析证书。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Stephanie H Chen et al.
Frontiers in pharmacology, 11, 607287-607287 (2021-02-12)
The inflammatory response appears to play a critical role in clotting in which neutrophil extracellular traps (NETs) are the major drivers of thrombosis in acute ischemic stroke (AIS). The inflammasome is an innate immune complex involved in the activation of
Hong-Mei Huang et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 22(9), 1027-1033 (2020-09-17)
To study whether pyroptosis is involved in the bilirubin-induced injury of primary cultured rat cortical microglial cells. Primary cultured rat cortical microglial cells were randomly administered with 30 μmol/L bilirubin (bilirubin group), 30 μmol/L bilirubin following 30 μmol/L VX-765 pretreatment
Jia-Feng Chang et al.
Life (Basel, Switzerland), 12(5) (2022-05-29)
We formerly proved that uremic vascular calcification (UVC) correlates tightly with oxidative elastic lamina (EL) injury and two cell fates (apoptosis and osteocytic conversion) in smooth muscle cells (SMC) of chronic kidney disease (CKD) patients and eliminating p-cresyl sulfate (PCS)-activated
Dong-Hua Zhou et al.
Molecular neurobiology (2024-04-26)
Neuroinflammation is a common pathological feature in a number of neurodegenerative diseases, which is mediated primarily by the activated glial cells. Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome-associated neuroinflammatory response is mostly considered. To investigate the situation of the
Claire Smalley et al.
PloS one, 11(6), e0157231-e0157231 (2016-07-01)
Rickettsiae actively escape from vacuoles and replicate free in the cytoplasm of host cells, where inflammasomes survey the invading pathogens. In the present study, we investigated the interactions of Rickettsia australis with the inflammasome in both mouse and human macrophages.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持