07-018-I
磷酸化p70 S6激酶（Tyr389）抗体
from rabbit, purified by affinity chromatography
别名:
Ribosomal protein S6 kinase, S6K-beta-1, S6K1, p70S6K1, p70 S6K1, p70-S6K1, p70 S6KA
产品名称
磷酸化p70 S6激酶（Tyr389）抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
zebrafish (based on 100% sequence homology), chicken (based on 100% sequence homology), rat (based on 100% sequence homology), bovine (based on 100% sequence homology), mouse (based on 100% sequence homology)
technique(s)
inhibition assay: suitable (peptide)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pThr389)
Quality Level
Gene Information
human ... RPS6KB1(6198)
Analysis Note
对照
MCF7细胞裂解液
MCF7细胞裂解液
通过蛋白质印迹（肽抑制）分析对MCF7细胞裂解液和含非磷酸化或磷酸化肽的MCF7细胞裂解液进行了评估。
蛋白质印迹（肽抑制）分析：1.0 µg/mL的该抗体在10 µg MCF7细胞裂解液和与非磷酸化肽一起孵育的MCF7细胞裂解液中检测到在Thr389处磷酸化的p70 S6激酶。
蛋白质印迹（肽抑制）分析：1.0 µg/mL的该抗体在10 µg MCF7细胞裂解液和与非磷酸化肽一起孵育的MCF7细胞裂解液中检测到在Thr389处磷酸化的p70 S6激酶。
Application
可使用这种磷酸化p70 S6激酶（Thr389）抗体检测磷酸化p70 S6激酶（Thr389），该抗体经验证可用于蛋白质印迹、肽抑制试验。
研究子类别
激酶 & 磷酸酶
激酶 & 磷酸酶
研究类别
信号传导
信号传导
Biochem/physiol Actions
其他同源性：核糖体蛋白S6激酶β-2（具有91%的序列同源性）。
该抗体可识别在Thr389处磷酸化的核糖体蛋白S6激酶β-1的AGC激酶C端。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
p70s6激酶是一种普遍存在的细胞质蛋白，在细胞因子和生长因子（包括表皮生长因子和成纤维细胞生长因子）的反应中被激活。它位于mTOR/PI3K通路的下游，在多个残基上被磷酸化：Thr389、Thr229、Thr421、Ser371、Ser404、Ser411、Ser418和Ser424。Thr389、Ser371和Ser404位于连接子结构域；而Thr421、Ser411、Ser418、Ser424位于自抑制结构域，Thr229位于催化结构域。这些位点可能按等级顺序被磷酸化，导致p70s6激酶的激活。p70 S6激酶磷酸化40S核糖体蛋白（rpS6）上的S6蛋白，参与5’端寡聚嘧啶束mRNA分子调控、蛋白合成、细胞生长、增殖和细胞存活等多个过程。这种激酶的活性可能在糖尿病、癌症和衰老中起重要作用。
观测值〜70 kDa
Immunogen
KLH偶联线性肽，对应于在Thr389处磷酸化的人核糖体蛋白S6激酶β-1的AGC激酶C末端。
表位：AGC激酶C端
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
亲和纯化
纯化的兔多克隆抗体，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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