07-404
抗-PRMT1抗体
Upstate®, from rabbit
别名:
Anti-ANM1, Anti-HCP1, Anti-HRMT1L2, Anti-IR1B4
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
mouse, human
Citations:
68
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
抗-PRMT1抗体, Upstate®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PRMT1(3276)
Analysis Note
对照
阳性抗原对照：货号12-303，Jurkat细胞裂解液。
阳性抗原对照：货号12-303，Jurkat细胞裂解液。
已通过免疫印迹法对Jurkat、3T3/A31、NIH 3T3、HeLa和小鼠ES细胞的裂解液进行了常规评估
Application
抗i-PRMT1 抗体是一种高质量的兔多克隆抗体，用于检测 PRMT1&已在 WB 中验证。
研究子类别
组蛋白
组蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
PRMT1 双联体（doublet）
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
42-44 kDa
精氨酸的甲基化是由精氨酸甲基转移酶（PRMT）家族的酶介导。这些酶将甲基从S-腺苷-L-甲硫氨酸转移到精氨酸残基的胍基氮。研究发现精氨酸甲基化是信号转导、转录、RNA转运和剪接的重要修饰手段。PRMT1（也称HRMT1L2 和 IR1B4）是通过其与细胞静止（cell quiescence）中的重要蛋白BTG1 和TIS21的相互作用而分离。PRMT1 是一种361个氨基酸的蛋白；其剪接变体的N末端不同，从而产生了343、361和347个氨基酸的三种亚型（分别为变体1、2、3）。涉及RNA 代谢的蛋白是PRMT1的底物，其中包括Sam68。
Immunogen
对应于人精氨酸甲基转移酶1的残基298-318的肽。
Physical form
0.1M Tris-甘氨酸（pH 7.4）、0.15M NaCl、0.05％叠氮化钠，然后添加甘油至30％
形式：纯化
纯化蛋白A
Preparation Note
在-20°C下可保存2年
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo.
Herrmann, F; Lee, J; Bedford, MT; Fackelmayer, FO
The Journal of Biological Chemistry null
Regulation of the EBNA1 Epstein-Barr virus protein by serine phosphorylation and arginine methylation.
Shire, K; Kapoor, P; Jiang, K; Hing, MN; Sivachandran, N; Nguyen, T; Frappier, L
Journal of virology null
Markus A Kleinschmidt et al.
Nucleic acids research, 36(10), 3202-3213 (2008-04-17)
Protein arginine methyltransferases (PRMT) have been implicated in the regulation of transcription. They are recruited to promoters via interaction with transcription factors and exert their coactivator function by methylating arginine residues in histones and other chromatin proteins. Here, we employ
Li Zhang et al.
eLife, 4 (2015-11-18)
RBM15, an RNA binding protein, determines cell-fate specification of many tissues including blood. We demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 (PRMT1) at residue R578, leading to its degradation via ubiquitylation by an E3 ligase (CNOT4). Overexpression
Arginine methylation of scaffold attachment factor A by heterogeneous nuclear ribonucleoprotein particle-associated PRMT1.
Herrmann, F; Bossert, M; Schwander, A; Akgun, E; Fackelmayer, FO
The Journal of Biological Chemistry null
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