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Merck
CN

07-452

抗-二甲基-组蛋白H3 (Lys27)抗体

Upstate®, from rabbit

别名:

H3K27me2, Histone H3 (di methyl K27)

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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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产品名称

抗-二甲基-组蛋白H3 (Lys27)抗体, Upstate®, from rabbit

biological source

rabbit

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

ChIP: suitable (ChIP-seq)
cell based assay: suitable
dot blot: suitable
multiplexing: suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_003493

UniProt accession no.

Q16695

shipped in

wet ice

target post-translational modification

dimethylation (Lys27)

Quality Level

100

Gene Information

human ... H3C1(8350)

相关类别

Analysis Note

对照
HeLa全细胞裂解液，U2OS细胞裂解液
通过免疫印迹对HeLa细胞的酸提取蛋白进行了常规评估。

Application

其他参考的研究应用：
斑点印迹，免疫细胞化学（细胞）
使用在Mplex、PIA、WB、ChIP-seq、DB中验证的抗二甲基组蛋白H3（Lys27）抗体（兔多克隆抗体）检测二甲基组蛋白H3（Lys27），也称为H3K27me2，组蛋白H3（二甲基K27）。
研究子类别
组蛋白
研究类别
表观遗传学&核功能

Biochem/physiol Actions

基于序列同源性，预期具有广泛的物种交叉反应
识别二甲基化的组蛋白H3（Lys27）。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

17 kDa
抗-二甲基-组蛋白H3（Lys27）

Immunogen

KLH缀合合成2X支肽，包含序列...ARme2KSA...，其中me2K对应于人组蛋白H3残基27处的二甲基赖氨酸。

Other Notes

浓度：请参考批次特异性浓缩物的分析证书。

Physical form

亲和纯化的IgG溶于0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl和0.05%NaN3中。
肽亲和纯化

Preparation Note

自运送之日起在2-8°C可稳定保存2年。

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5.
Xu, CR; Schaffer, L; Head, SR; Feeney, AJ
Proceedings of the National Academy of Sciences of the USA null
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes.
Silva, Jose, et al.
Developmental Cell, 4, 481-495 (2003)
Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune response.
Wen, H; Dou, Y; Hogaboam, CM; Kunkel, SL
Blood null
Elian Perruc et al.
The Plant journal : for cell and molecular biology, 52(5), 927-936 (2007-09-26)
Embryogenesis in Arabidopsis results in mature, osmotolerant embryos within dry seeds. Late-embryogenesis programs involve the transcription factors ABI3 and ABI5, which are necessary for osmotolerance. ABI3 and ABI5 are degraded in seeds initiating germination, abolishing their protected state. However, during
Kohta Ikegami et al.
Genes to cells : devoted to molecular & cellular mechanisms, 12(1), 1-11 (2007-01-11)
In the mammalian genome, numerous CpG-rich loci define tissue-dependent and differentially methylated regions (T-DMRs). Euchromatin from different cell types differs in terms of its tissue-specific DNA methylation profile as defined by these T-DMRs. G9a is a euchromatin-localized histone methyltransferase (HMT)
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