生物来源
rabbit
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human, rat
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
phosphorylation (pThr172)
基因信息
human ... PRKAA1(5562)
一般描述
Mr 63 kDa
免疫原
KLH偶联的合成肽，对应于人AMP活化蛋白激酶α2（AMPKα2）的磷酸化Thr172周围的氨基酸。
应用
抗磷酸化AMPK α（Tyr342）抗体是针对磷酸化AMPKα（Tyr342）的抗体，可用于WB。
生化/生理作用
可识别磷酸化AMPKα。
外形
形式：纯化
分析说明
对照
血清饥饿HEK293 细胞
血清饥饿HEK293 细胞
已通过免疫印迹对过夜饥饿的HEK293 细胞和部分纯化的大鼠肝脏AMPK的RIPA裂解液进行了常规评估
其他说明
浓度：请参考批次特异性浓缩物的检验报告。
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
Mathias Fasshauer et al.
Biochimie, 86(11), 779-784 (2004-12-14)
Several adipocyte-secreted factors have been demonstrated to potentially link obesity, insulin resistance, and cardiovascular disease. Among those, adiponectin is an insulin-sensitizing and anti-inflammatory adipokine, concentrations of which are decreased in obesity-associated metabolic and vascular disorders. Recently, two adiponectin receptors (AdipoR)
Tue L Nielsen et al.
Molecular genetics and metabolism, 123(1), 21-27 (2017-11-28)
McArdle disease (glycogen storage disease type V) is an inborn error of skeletal muscle metabolism, which affects glycogen phosphorylase (myophosphorylase) activity leading to an inability to break down glycogen. Patients with McArdle disease are exercise intolerant, as muscle glycogen-derived glucose
Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis.
Rutter, Guy A, et al.
The Biochemical Journal, 375, 1-16 (2003)
B E Kemp et al.
Biochemical Society transactions, 31(Pt 1), 162-168 (2003-01-28)
The AMP-activated protein kinase (AMPK) is a metabolic-stress-sensing protein kinase that regulates metabolism in response to energy demand and supply by directly phosphorylating rate-limiting enzymes in metabolic pathways as well as controlling gene expression.
Enhanced external counterpulsation improves peripheral artery function and glucose tolerance in subjects with abnormal glucose tolerance.
Martin, JS; Beck, DT; Aranda, JM; Braith, RW
Journal of Applied Physiology (1985)
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