biological source
rabbit
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, rat
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pThr172)
Gene Information
human ... PRKAA1(5562)
General description
Mr 63 kDa
Immunogen
KLH偶联的合成肽，对应于人AMP活化蛋白激酶α2（AMPKα2）的磷酸化Thr172周围的氨基酸。
Application
抗磷酸化AMPK α（Tyr342）抗体是针对磷酸化AMPKα（Tyr342）的抗体，可用于WB。
Biochem/physiol Actions
可识别磷酸化AMPKα。
Physical form
形式：纯化
Analysis Note
对照
血清饥饿HEK293 细胞
血清饥饿HEK293 细胞
已通过免疫印迹对过夜饥饿的HEK293 细胞和部分纯化的大鼠肝脏AMPK的RIPA裂解液进行了常规评估
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
B E Kemp et al.
Biochemical Society transactions, 31(Pt 1), 162-168 (2003-01-28)
The AMP-activated protein kinase (AMPK) is a metabolic-stress-sensing protein kinase that regulates metabolism in response to energy demand and supply by directly phosphorylating rate-limiting enzymes in metabolic pathways as well as controlling gene expression.
Tue L Nielsen et al.
Molecular genetics and metabolism, 123(1), 21-27 (2017-11-28)
McArdle disease (glycogen storage disease type V) is an inborn error of skeletal muscle metabolism, which affects glycogen phosphorylase (myophosphorylase) activity leading to an inability to break down glycogen. Patients with McArdle disease are exercise intolerant, as muscle glycogen-derived glucose
Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis.
Rutter, Guy A, et al.
The Biochemical Journal, 375, 1-16 (2003)