07-758
抗磷-Flt-1 (Tyr1213)抗体
Upstate®, from rabbit
别名:
Vascular endothelial growth factor receptor 1 (VEGFR-1), Vascular permeability factor receptor, Tyrosine-protein kinase FRT, Fms-like tyrosine kinase
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
bovine, human, goat, sheep, rat, mouse
Application:
WB
Citations:
18
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
bovine, human, goat, sheep, rat, mouse
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pTyr1213)
Gene Information
bovine ... Flt1(503620)
human ... FLT1(2321)
mouse ... Flt1(14254)
rat ... Flt1(54251)
General description
~180 kDa（QC检测片段为66 kDa）
Immunogen
KLH缀合的合成肽，包含序列(...VR[pY]VN...)，其中[pY]对应于人Flt-1残基1213处的磷酸酪氨酸。免疫序列在狨猴中相同，在大鼠、山羊、绵羊、奶牛和恒河猴中有14/15个相同氨基酸，在小鼠中有13/15个相同氨基酸。
Application
抗磷酸-Flt-1 (Tyr1213)抗体可检测磷酸-Flt-1 (Tyr1213)水平 & 已发布 & 经验证可用于WB。
研究子范畴
生长因子 & 受体
生长因子 & 受体
研究类别
信号传导
信号传导
Biochem/physiol Actions
识别磷酸-Flt-1 (Tyr1213)。
Physical form
免疫亲和性纯化兔IgG ，溶于0.1 Tris-甘氨酸（pH 7.4）、0.15 NaCl和0.05％叠氮化钠中。
免疫亲和纯化
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。 避免反复冻融循环，以免损坏IgG和影响产品性能。
Analysis Note
对照
重组Flt-1（目录号14-562）被ATP磷酸化
重组Flt-1（目录号14-562）被ATP磷酸化
通过免疫印迹法对ATP孵育后磷酸化的重组Flt-1（目录号14-562）进行常规评估
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
Zheng Zhou et al.
American journal of cancer research, 5(10), 3149-3161 (2015-12-23)
Angiogenesis is central to the growth of cancers and VEGFR-1/Flt-1 plays an important role during the neovascularization under pathological conditions. We previously founded a VEGFR1 antagonistic peptide, F56, by screening the phage peptide library. We showed that DHFR-F56 chimeric protein
Chuanke Zhao et al.
Cancer science, 106(11), 1596-1606 (2015-08-25)
Angiogenesis is a prerequisite of tumor growth and metastasis and, thus, anti-angiogenesis treatment has become an important part of cancer therapy. A 15-amino acid peptide of the fibrinogen α chain, fibrinostatin, was previously found in serum samples of gastric cancer
Paul Mésange et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(11), 2548-2558 (2018-03-02)
Purpose: There is extensive cross-talk between VEGF- and EGFR-pathway signaling in colorectal cancer. However, combinations of VEGF- and EGFR-targeted monoclonal antibodies (mAb) show disappointing activity, in particular for patients with mutant RAS Previous results show that tyrosine kinase inhibitors (TKI)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 07-758 | 04053252673634 |