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Merck
CN

16-256

抗磷脂酰丝氨酸抗体，克隆1H6，Alexa Fluor™ 488

clone 1H6, Upstate®, from mouse

别名:

488-Alexa Fluor抗体, Alexa Fluor 488检测, 克隆1H6抗磷脂酰丝氨酸抗体

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

主要文件

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产品名称

抗磷脂酰丝氨酸抗体，克隆1H6，Alexa Fluor™ 488, clone 1H6, Upstate®, from mouse

biological source

mouse

conjugate

ALEXA FLUOR™ 488

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1H6, monoclonal

species reactivity

vertebrates

manufacturer/tradename

Upstate®

technique(s)

flow cytometry: suitable

isotype

IgG

shipped in

wet ice

target post-translational modification

phosphorylation (pSer)

Quality Level

100

相关类别

Analysis Note

对照
阴性对照：目录号16-240，正常小鼠IgG，Alexa Fluor™ 488-偶联物。
流式细胞术： 0.2 μg该抗体可在固定Jurkat细胞中检测出磷脂酰丝氨酸（见第2页）。

凋亡测定：使用抗磷脂酰丝氨酸，克隆1H6，Alexa Fluor™ 488偶联物或膜联蛋白V FITC偶联物测量星形孢菌素对Jurkat细胞中凋亡诱导的时间过程。

Application

使用经验证可用于FC的抗磷脂酰丝氨酸抗体（克隆1H6，Alexa Fluor 488）检测磷脂酰丝氨酸。
研究子类别
凋亡-附加
研究类别
细胞凋亡 & 癌症

Biochem/physiol Actions

识别细胞膜中的磷脂酰丝氨酸（PS）

Disclaimer

Alexa Fluor™是Molecular Probes, Inc.的注册商标。

除非在产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得对人或动物用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用。

General description

意义：
抗磷脂酰丝氨酸可用于检测膜磷脂磷脂酰丝氨酸（PS）从内膜小叶向外膜小叶的移位；它提供了膜联蛋白V的替代方法，用于定量细胞凋亡。
磷脂酰丝氨酸或PS是天然存在的磷脂营养素。PS对所有人体细胞的功能至关重要，但最集中在大脑中。它在该器官中的相对丰度反映了它已被证明参与了各种神经细胞功能，包括神经递质释放和突触活性。临床研究表明，PS可以支持随着年龄增长而下降的大脑功能。

Immunogen

含有70%磷脂酰丝氨酸和30%磷脂酰甘油的脂质体。

Other Notes

浓度：请参考批次特异性浓缩物的检验报告。

Physical form

纯化的小鼠单克隆IgG，溶于含有PBS、1% BSA、0.05％吐温和0.05％叠氮化钠的缓冲液中。 在4ºC为液体形式。
蛋白G纯化

Preparation Note

自收到之日起可稳定保存1年。

Legal Information

ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Yi An et al.
Scientific reports, 11(1), 6392-6392 (2021-03-20)
Head and neck squamous cell carcinomas (HNSCC) induced by human papillomavirus (HPV) have increased recently in the US. However, the distinct alterations of molecules involved in the death pathways and drug effects targeting inhibitor of apoptosis proteins (IAPs) have not
Carlos E Bravo-Iñiguez et al.
Nature communications, 14(1), 3122-3122 (2023-06-02)
Deficiency of coagulation factor VIII in hemophilia A disrupts clotting and prolongs bleeding. While the current mainstay of therapy is infusion of factor VIII concentrates, inhibitor antibodies often render these ineffective. Because preclinical evidence shows electrical vagus nerve stimulation accelerates
Yuta Nakazawa et al.
eLife, 10 (2021-11-10)
Although tumor-infiltrating regulatory T (Treg) cells play a pivotal role in tumor immunity, how Treg cell activation are regulated in tumor microenvironments remains unclear. Here, we found that mice deficient in the inhibitory immunoreceptor CD300a on their dendritic cells (DCs)
I Vermes et al.
Journal of immunological methods, 184(1), 39-51 (1995-07-17)
In the early stages of apoptosis changes occur at the cell surface, which until now have remained difficult to recognize. One of these plasma membrane alterations is the translocation of phosphatidylserine (PS) from the inner side of the plasma membrane
Sadna Budhu et al.
Cell reports, 34(2), 108620-108620 (2021-01-14)
Phosphatidylserine (PS) is exposed on the surface of apoptotic cells and is known to promote immunosuppressive signals in the tumor microenvironment (TME). Antibodies that block PS interaction with its receptors have been shown to repolarize the TME into a proinflammatory
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