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Merck
CN

16-272

抗乙酰赖氨酸抗体,克隆 4G12,琼脂糖偶联物

clone 4G12, Upstate®, from mouse

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
4G12, monoclonal
Technique(s):
immunoprecipitation (IP): suitable
Application:
IP
Citations:
6
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biological source

mouse

antibody form

purified antibody

antibody product type

primary antibodies

clone

4G12, monoclonal

species reactivity (predicted by homology)

all

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable

shipped in

wet ice

target post-translational modification

acetylation (Lys)

Quality Level

General description

因检测的蛋白质而异。

Immunogen

化学乙酰化抗原的混合物。 克隆4G12。

Application

用抗乙酰赖氨酸抗体(克隆4G12,琼脂糖偶联物,小鼠单克隆抗体)检测乙酰赖氨酸,该抗体已被证明可在IP中起作用。
研究亚类
常规翻译后修饰

组蛋白
研究类别
信号传导

表观遗传学&核功能

Biochem/physiol Actions

识别含乙酰赖氨酸的蛋白质,包括组蛋白。

Features and Benefits

形式:凝胶固定

Preparation Note

自发货之日起在4°C下可保存1年。不可冷冻。

Analysis Note

通过免疫沉淀进行了常规评估。

Other Notes

浓度:请参考批次特异性浓缩物的检验报告。

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Yan Liu et al.
Journal of proteome research, 20(5), 2596-2606 (2021-04-02)
Decreased cellular NAD+ levels are causally linked to aging and aging-associated diseases. NAD+ precursors in oxidized form such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) have gained much attention and been well studied for their ability to restore NAD+
A Villagra et al.
Methods in enzymology, 573, 161-181 (2016-07-04)
Histone deacetylase assays were first developed in the 1970s, and subsequently refined in the 1990s with the cloning of HDAC enzymes. Most of these early assays, relying on traditional in vitro chemical methodologies, are still applicable today. More recently, however
Acetylation of general transcription factors by histone acetyltransferases.
Imhof, A, et al.
Current Biology, 7, 689-692 (1997)
Fei Yue et al.
Aging, 7(10), 839-853 (2015-11-06)
Autophagy controls and executes the turnover of abnormally aggregated proteins. MAP1S interacts with the autophagy marker LC3 and positively regulates autophagy flux. HDAC4 associates with the aggregation-prone mutant huntingtin protein (mHTT) that causes Huntington's disease, and colocalizes with it in

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