biological source
Porcine kidney
Quality Level
form
suspension (crystalline)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
physiological buffer: soluble, water: soluble
foreign activity
Oxidases ≤3%
shipped in
ambient
storage temp.
2-8°C
General description
氨基肽酶M（APM）大量存在于肾、小肠、胎盘、肝脏的刷状缘膜（brush border membrane）。它是一种II型整合膜蛋白，也称为胞外酶。
Application
猪肾氨基肽酶M已用于：
- 测试并鉴定促咽侧体神经肽相关肽（ATRP）中的含d-残基峰
- 研究其对酶活性的氧化失活并筛查MIRA成分
- 异缩酮（IsoLG）蛋白的蛋白水解
Biochem/physiol Actions
氨基肽酶M（APM）与大脑中某些神经肽（如脑啡肽和血管紧缩素）作用的终止有关。它也代谢某些血管活性肽。它可作为某些病毒（如冠状病毒229E）的受体。APM是一种非特异性肽酶，可快速裂解I-残基肽。
Packaging
请参考特定浓度批号的标签。
Physical form
在3.2 M (NH₄)₂SO₄、10 mM MgCl₂、10 mM Tris-HCl（pH 7.5）中的晶体混悬液。
Other Notes
Wachsmuth, E.E., et al. 1966.Biochemistry5, 169.
一个单位定义为在37°C，pH 7.2下，每分钟水解1 µ mol Leu-pNA的酶量。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有害（C）
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Handbook of Proteolytic Enzymes (2012)
Oral Delivery of Peptide Formulations and Their Cellular Evaluation
Patil S, et al.
International Journal of Peptide Research and Therapeutics, 27(4), 2831-2844 (2021)
James W Checco et al.
The Journal of biological chemistry, 293(43), 16862-16873 (2018-09-09)
l- to d-residue isomerization is a post-translational modification (PTM) present in neuropeptides, peptide hormones, and peptide toxins from several animals. In most cases, the d-residue is critical for the biological function of the resulting d-amino acid-containing peptide (DAACP). Here, we
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 164598-50U | 04055977207576 |