182690
AhR激动剂V，VAF347
The AhR Agonist V, VAF347 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.
别名:
AhR激动剂V，VAF347
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关于此项目
经验公式（希尔记法）:
C17H11ClF3N3
化学文摘社编号:
分子量:
349.74
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.51
PubChem Substance ID:
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
C1=CC(=CC(=C1)Cl)C2=NC(=NC=C2)NC3=CC=C(C=C3)C(F)(F)F
InChI key
XTKUZTBZRIJTFR-UHFFFAOYSA-N
General description
一种细胞可渗透的嘧啶基苯胺化合物，以高亲和力直接并可逆地靶向芳烃受体（AhR），并诱导AhR信号传导。据报道可作为一种具有抗炎特性的免疫调节剂。强效抑制B细胞中的IgE分泌，IC50约为2 nM，并抑制树突状细胞介导的T细胞增殖和细胞因子产生。此外，减少B细胞缺陷小鼠的肺嗜酸粒细胞增多症和过敏性炎症。下调PU.1转录因子，损害人单核细胞和朗格汉斯树突状细胞分化。
Packaging
用惰性气体包装
Other Notes
Platzer, B., et al. 2009.J. Immunol.183, 66.
Hauben, E., et al. 2008.Blood118, 1214.
Lawrence, B.P., et al. 2008.Blood112, 1158.
Ettmayer, P., et al. 2006.Am. J. Respir.Crit.Care Med.173, 599.
Hauben, E., et al. 2008.Blood118, 1214.
Lawrence, B.P., et al. 2008.Blood112, 1158.
Ettmayer, P., et al. 2006.Am. J. Respir.Crit.Care Med.173, 599.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 182690-10MG | 04055977204445 |