196419
BAPTA/AM
Membrane-permeable form of BAPTA.
别名:
BAPTA/AM, 1,2-双（o-氨基苯氧基）乙烷-N,N,Nʹ,Nʹ-四乙酸四（乙酰氧基甲基）酯
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选择尺寸
关于此项目
经验公式（希尔记法）:
C34H40N2O18
化学文摘社编号:
分子量:
764.68
UNSPSC Code:
12352108
NACRES:
NA.25
MDL number:
产品名称
BAPTA/AM, Membrane-permeable form of BAPTA.
SMILES string
N(CC(=O)OCOC(=O)C)(CC(=O)OCOC(=O)C)c1c(cccc1)OCCOc2c(cccc2)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C
InChI
1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3
InChI key
YJIYWYAMZFVECX-UHFFFAOYSA-N
assay
≥90% (TLC)
form
solid
reaction suitability
reagent type: chelator
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
light yellow
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Application
- TRPV1-Dependent Antiproliferative Activity of Dioecious Maclura pomifera Extracts in Estrogen Receptor-Positive Breast Cancer Cell Lines Involves Multiple Apoptotic Pathways.：本文研究如何通过调节乳腺癌细胞中的TRPV1和凋亡通路发挥抗增殖作用，过程中用到钙螯合剂BAPTA/AM(Rumpa et al., 2024)。
- Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence.：本文体现BAPTA/AM可缓解与肾细胞衰老和肾脏老化过程有关的线粒体钙超载(Xiong et al., 2024)。
- TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis.：本文研究TRPV3通道如何通过激活NRF2/FSP1通路增强脂解和抗肥胖保护，BAPTA/AM在通道调节实验中起作用(Hu et al., 2024)。
- Inflammation and Acinar Cell Dual-Targeting Nanomedicines for Synergistic Treatment of Acute Pancreatitis via Ca(2+) Homeostasis Regulation and Pancreas Autodigestion Inhibition.：使用BAPTA/AM调节钙稳态以抑制急性胰腺炎治疗导致的炎症和自身消化(Wang et al., 2024)。
- IP(3)R-Mediated Calcium Release Promotes Ferroptotic Death in SH-SY5Y Neuroblastoma Cells.：本文研究BAPTA/AM如何抑制IP3R介导的钙释放，从而减少神经母细胞瘤细胞铁死亡(Campos et al., 2024)。
Disclaimer
毒性：刺激性（B）
General description
BAPTA膜透过形式。可以加载到各种各样的细胞中，在其中它被胞质酯酶水解，并作为活性螯合剂BAPTA捕获在细胞内。防止可卡因引起的心室纤颤。消除维生素D3诱导的细胞内Ca2+增加。诱导蛋白激酶C失活。还抑制毒胡萝卜素诱导的大鼠胸腺细胞凋亡。
Other Notes
Bissonnette, M., et al. 1994.Am. J. Physiol.267, G465.
Jiang, S., et al. 1994.Exp.Cell Res.212, 84.
Billman, G.E.1993.Am. J. Physiol.265, H1529.
Dieter, P., et al. 1993.Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M.1987.Biochim.Biophys.Acta 925, 133.
Harrison, S.M., and Bers, D.M.1987.J. Biophys.51, 102A.
Marban, E., et al. 1986.J. Clin. Invest.78, 1185.
Tsien, R.Y.1981.Nature290, 527.
Tsien, R.Y.1980.Biochemistry19, 2396.
Jiang, S., et al. 1994.Exp.Cell Res.212, 84.
Billman, G.E.1993.Am. J. Physiol.265, H1529.
Dieter, P., et al. 1993.Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M.1987.Biochim.Biophys.Acta 925, 133.
Harrison, S.M., and Bers, D.M.1987.J. Biophys.51, 102A.
Marban, E., et al. 1986.J. Clin. Invest.78, 1185.
Tsien, R.Y.1981.Nature290, 527.
Tsien, R.Y.1980.Biochemistry19, 2396.
Packaging
用惰性气体包装
Preparation Note
复溶后，分装，用惰性气体吹扫，然后冻存（-20°C）。储备液可在-20°C最长稳定1个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Beatriz Cristovao et al.
Microbiology spectrum, 11(5), e0123823-e0123823 (2023-09-21)
Phagolysosomes are crucial organelles during the elimination of pathogens by host cells. The maintenance of their membrane integrity is vital during stressful conditions, such as during Candida albicans infection. As the fungal hyphae grow, the phagolysosome membrane expands to ensure
Xin-Yi Wu et al.
Oxidative medicine and cellular longevity, 2022, 8123157-8123157 (2022-03-15)
Although a recent study reported that stimulator of interferon genes (STING) in macrophages has an important regulatory effect on liver ischemia-reperfusion injury (IRI), the underlying mechanism of STING-dependent innate immune activation in liver macrophages (Kupffer cells, KCs) remains unclear. Here
Noman Hassan et al.
iScience, 27(1), 108629-108629 (2024-01-08)
Since the early seminal studies on epithelial solute transport, it has been understood that there must be crosstalk among different members of the transport machinery to coordinate their activity and, thus, generate localized electrochemical gradients that force solute flow in
Sarah M Zych et al.
Cell reports, 39(7), 110823-110823 (2022-05-19)
Substantia nigra pars compacta (SNc) dopamine neurons play a key role in regulating the activity of striatal circuits within the basal ganglia. In addition to dopamine, these neurons release several other transmitters, including the major inhibitory neurotransmitter γ-aminobutyric acid (GABA).
Javier Campos-Gómez et al.
American journal of physiology. Lung cellular and molecular physiology, 324(4), L493-L506 (2023-02-23)
The coronavirus disease (COVID-19) pandemic, caused by SARS-CoV-2 coronavirus, is devastatingly impacting human health. A prominent component of COVID-19 is the infection and destruction of the ciliated respiratory cells, which perpetuates dissemination and disrupts protective mucociliary transport (MCT) function, an
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