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经验公式(希尔记法):
C24H28O2
化学文摘社编号:
分子量:
348.48
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
贝沙罗汀, A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner.
SMILES string
OC(=O)c1ccc(cc1)C(=C)c2cc3c(cc2C)C(CCC3(C)C)(C)C
InChI
1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
InChI key
NAVMQTYZDKMPEU-UHFFFAOYSA-N
assay
≥96% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white to orange
solubility
DMSO: 50 mg/mL, clear, colorless
shipped in
ambient
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
细胞可渗透性:是
可逆性:是
Disclaimer
毒性:监管审查(Z)
General description
一种类视黄醇X受体(RXR)激动剂,可以渗透血脑屏障并以ApoE依赖性方式迅速降低APP/PS1小鼠中的Aβ40和Aβ42水平(6小时减少25%,72小时减少50%)。导致认知,社交和嗅觉缺陷的快速逆转。显示逐渐增强ApoE和ATP结合盒转运蛋白ABCA1和ABCG1的表达。 还刺激初级小胶质细胞和星形胶质细胞中高度脂化的HDL颗粒的分泌。不影响Aβ蛋白酶、胰岛素降解酶和脑啡肽酶的水平。
Other Notes
Cramer, P.E., et al. 2012.Science Exp.335, 1503.
Packaging
用惰性气体包装
Preparation Note
复溶后,等分并冷冻保存(-20°C)。储备液在-20°C条件下可稳定保存6个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Haihai Dong et al.
Folia neuropathologica, 58(3), 253-264 (2020-10-26)
Traumatic brain injury (TBI) is the leading cause of death and disability around the world in all age groups. The primary injury of TBI is exacerbated by secondary injury, leading to an increased inflammatory response, cell death and even impairment
Che-Feng Chang et al.
Stroke, 51(2), 612-618 (2019-12-13)
Background and Purpose- Enhancement of erythrophagocytosis by macrophages in a timely manner can limit the toxic effects of erythrocyte metabolites and promote brain recovery after intracerebral hemorrhage (ICH). In the current study, we investigated the therapeutic effect of retinoid X
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