200499
贝沙罗汀
≥96% (HPLC), retinoid X receptor agonist, powder
别名:
贝沙罗汀, 4-（1-（3,5,5,8,8-五甲基-5,6,7,8-四氢萘-2-基）乙烯基）苯甲酸
产品名称
贝沙罗汀, A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner.
质量水平
方案
≥96% (HPLC)
表单
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white to orange
溶解性
DMSO: 50 mg/mL, clear, colorless
运输
ambient
储存温度
−20°C
SMILES字符串
OC(=O)c1ccc(cc1)C(=C)c2cc3c(cc2C)C(CCC3(C)C)(C)C
InChI
1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
InChI key
NAVMQTYZDKMPEU-UHFFFAOYSA-N
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一般描述
一种类视黄醇X受体（RXR）激动剂，可以渗透血脑屏障并以ApoE依赖性方式迅速降低APP/PS1小鼠中的Aβ40和Aβ42水平（6小时减少25%，72小时减少50%）。导致认知，社交和嗅觉缺陷的快速逆转。显示逐渐增强ApoE和ATP结合盒转运蛋白ABCA1和ABCG1的表达。 还刺激初级小胶质细胞和星形胶质细胞中高度脂化的HDL颗粒的分泌。不影响Aβ蛋白酶、胰岛素降解酶和脑啡肽酶的水平。
生化/生理作用
可逆性：是
细胞可渗透性：是
包装
用惰性气体包装
制备说明
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存6个月。
其他说明
Cramer, P.E., et al. 2012.Science Exp.335, 1503.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：监管审查（Z）
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Haihai Dong et al.
Folia neuropathologica, 58(3), 253-264 (2020-10-26)
Traumatic brain injury (TBI) is the leading cause of death and disability around the world in all age groups. The primary injury of TBI is exacerbated by secondary injury, leading to an increased inflammatory response, cell death and even impairment
Che-Feng Chang et al.
Stroke, 51(2), 612-618 (2019-12-13)
Background and Purpose- Enhancement of erythrophagocytosis by macrophages in a timely manner can limit the toxic effects of erythrocyte metabolites and promote brain recovery after intracerebral hemorrhage (ICH). In the current study, we investigated the therapeutic effect of retinoid X
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