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Merck
CN

204903

抗补体5b-9 兔pAb

liquid, Calbiochem®

别名:

抗末端补体复合物,抗膜攻击复合物,抗MAC

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关于此项目

NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
human, mouse
Application:
Citations:
18
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biological source

rabbit

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

human, mouse

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

dilution

(Frozen Sections
Immunofluorescence
Paraffin Sections (heat pre-treatment required)
Radial Immunodiffusion (use undiluted))

isotype

IgG

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

General description

蛋白A纯化的兔多克隆抗体。识别C5b-C9 补体成分复合物。
识别补体成分复合物 Cb5-C9。
该抗补体5b-9兔pAb经验证可用于冷冻切片、免疫荧光、石蜡切片、径向免疫扩散以检测补体5b-9。

Immunogen

纯化的人 SC5b-9 复合物

Application

冷冻切片(参见应用参考)

免疫荧光(参见注释)

石蜡切片(参见注释,需要加热预处理)

径向免疫扩散 (使用未稀释产品)

Packaging

请参考特定浓度批号的标签。

Physical form

在PBS,pH 7.2中。

Preparation Note

初次解冻后,分装并冷冻保存(-20°C)。

Other Notes

Schafer, H., et al. 1986.J. Immunol.137, 1945.
通过免疫扩散,该抗体对纯化形式或存在于眼镜蛇毒因子激活的人血清中的 C5b-9 复合物具有单特异性。与未活化的正常人血清或血浆没有反应性。据报道还用于免疫荧光。该抗体适用于福尔马林固定的石蜡切片; 抗原修复需要使用柠檬酸盐缓冲液和高压锅蒸煮1 分钟。在单个系统中,应对抗体进行滴定以获得最佳结果。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性:标准处理(A)


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存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



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Melina V Jones et al.
Journal of immunology research, 2018, 9034695-9034695 (2019-01-17)
To reduce immune-mediated damage in a rat model of neuromyelitis optica (NMO) by blocking neutrophil migration using SCH527123, a drug that inhibits CXCR2. Neuromyelitis optica is a relapsing autoimmune disease that preferentially targets the optic nerves and spinal cord leading
Jean F Regal et al.
Molecular immunology, 78, 38-47 (2016-09-03)
Preeclampsia is characterized by development of hypertension during pregnancy and reduced placental perfusion. Previous studies in a rat model of placental ischemia-induced hypertension demonstrated that inhibiting complement activation attenuated increased maternal blood pressure with C3a and C5a identified as the
Mohammed Alshareef et al.
International journal of molecular sciences, 24(12) (2023-06-28)
Germinal matrix hemorrhage (GMH) is a pathology that occurs in infancy, with often devastating long-term consequences. Posthemorrhagic hydrocephalus (PHH) can develop acutely, while periventricular leukomalacia (PVL) is a chronic sequala. There are no pharmacological therapies to treat PHH and PVL.



全球贸易项目编号

货号GTIN
204903-1MG04055977219876