217570
抗-CD3小鼠mAb (UCHT1)
liquid, >95% (immunoglobulin, SDS-PAGE), clone UCHT1
别名:
CD3检测抗体, 小鼠抗CD3抗体, 抗CD3抗体
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关于此项目
NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
UCHT1, monoclonal
Species reactivity:
human
Application:
Citations:
7
产品名称
抗-CD3小鼠mAb (UCHT1), liquid, >95% (immunoglobulin, SDS-PAGE), clone UCHT1
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
UCHT1, monoclonal
assay
>95% (immunoglobulin, SDS-PAGE)
form
liquid
contains
0.5 mg/mL gentamycin sulfate as preservative
species reactivity
human
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
dilution
(Flow Cytometry (5 µg/mL)
Frozen Sections
Immunoprecipitation
T cell Co-stimulation )
isotype
IgG1
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Application
流式细胞术（5 µg/ml）
冷冻切片（参见备注）
免疫沉淀法（参见备注）
T细胞共刺激（参见应用参考）
冷冻切片（参见备注）
免疫沉淀法（参见备注）
T细胞共刺激（参见应用参考）
Disclaimer
毒性：标准处理（A）
General description
抗CD3，小鼠单克隆，克隆UCHT1，可识别人外周T细胞中CD3复合物的ε-链。已针对冰冻切片的FC，IP，IHC和T细胞共刺激进行了验证。
蛋白A纯化的小鼠单克隆抗体。识别CD3 T细胞受体复合物的~20 kDaε链。
识别人外周T细胞中CD3复合物的ε-链。可用于激活表达CD3ε的T细胞。
Immunogen
人胸腺细胞/Sezary T细胞
Other Notes
Thibault, G. and Bardos, P. 1995.J. Immunol.154, 3814.
Beverley, P.C., and Callard, R.E.1981.Eur. J. Immunol.11, 329.
Beverley, P.C., and Callard, R.E.1981.Eur. J. Immunol.11, 329.
该抗体可用于激活表达CD3ε的T细胞（见应用参考）。对5×105培养的HPB-MLT人肿瘤细胞进行FACS。当与二级试剂山羊抗小鼠IgG（FITC偶联）一起使用时，测试的最佳结合浓度为5 µg/mL。据报道，该抗体可用于免疫沉淀和冷冻切片染色。合适的工作稀释度由与测定条件相关的变量决定。
Packaging
请参考特定浓度批号的标签。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Wenmin Ji et al.
American journal of cancer research, 13(11), 5218-5235 (2023-12-07)
This research is dedicated to investigating the mechanism of programmed cell death ligand 1 (PD-L1) and tumor protein 53 target gene 1 (TP53TG1) in immune regulation of colon cancer (CC). Expressions of TP53TG1, PD-L1 and signal transducers and activators of
Xiaofei Gao et al.
Frontiers in immunology, 13, 799331-799331 (2022-03-18)
Trace element iron affects T cell biology, but the knowledge about the role of iron in regulating Treg cell expansion is limited. Treg cells play an important role in keeping peripheral T cell tolerance, increasing Treg cell expansion is a
Mengting Chen et al.
International journal of biological sciences, 19(16), 5160-5173 (2023-11-06)
Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells. Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and
Zijun Wang et al.
The Journal of clinical investigation, 130(7), 3717-3733 (2020-03-20)
T follicular helper (Tfh) cells are indispensable for the formation of germinal center (GC) reactions, whereas T follicular regulatory (Tfr) cells inhibit Tfh-mediated GC responses. Aberrant activation of Tfh cells contributes substantially to the pathogenesis of autoimmune diseases, such as
Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.
Javier Robles-Valero et al.
The EMBO journal, 40(22), e108125-e108125 (2021-10-08)
Mutations in VAV1, a gene that encodes a multifunctional protein important for lymphocytes, are found at different frequencies in peripheral T-cell lymphoma (PTCL), non-small cell lung cancer, and other tumors. However, their pathobiological significance remains unsettled. After cataloguing 51 cancer-associated
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