344216
WKYMVm
≥95% (HPLC), Formyl Peptide Receptor-Like 1 Agonist, lyophilized
别名:
Formyl Peptide Receptor-Like 1 Agonist, WKYMVm, H₂N-WKYMV- D-M-CONH2, FPRL1 Agonist, WKYMVm, H₂N-WKYMV-D-M-CONH2, FPRL1 Agonist, WKYMVm
产品名称
Formyl Peptide Receptor-Like 1 Agonist, WKYMVm, The Formyl Peptide Receptor-Like 1 Agonist, WKYMVm controls the biological activity of Formyl Peptide Receptor-Like 1. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
assay
≥95% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
solubility
DMSO: 10 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca2+] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue.
Biochem/physiol Actions
Cell permeable: no
EC50 = 510 pM in activating phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells
Primary Target
Formyl Peptide Receptor-Like 1
Formyl Peptide Receptor-Like 1
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Bae, Y.S., et al. 2004. J. Immunol.173, 607.
Bae, Y.S., et al. 2003. Mol. Pharmacol.64, 841.
Le, Y., et al. 1999. J. Immunol.163, 6777.
Seo, J.K., et al. 1997. J. Immunol.158, 1895.
Baek, S.H., et al. 1996. J. Biol. Chem.271, 8170.
Bae, Y.S., et al. 2003. Mol. Pharmacol.64, 841.
Le, Y., et al. 1999. J. Immunol.163, 6777.
Seo, J.K., et al. 1997. J. Immunol.158, 1895.
Baek, S.H., et al. 1996. J. Biol. Chem.271, 8170.
H-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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