36-003
抗磷酸化MYPT1（Thr850）抗体
Upstate®, from rabbit
别名:
Anti-GUBS, Anti-M130, Anti-MBS, Anti-MYPT1
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选择尺寸
关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
chicken, rat, human, mouse
Application:
WB
Citations:
43
biological source
rabbit
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
chicken, rat, human, mouse
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pThr850)
Quality Level
Gene Information
human ... PPP1R12A(4659)
General description
80 kDa
Immunogen
对应于鸡MYPT1氨基酸残基845-855的肽；该序列与人MYPT1的氨基酸848-858相同，853位有磷酸化Thr。
Application
使用经验证可用于WB的该抗磷酸化MYPT1（Thr850）抗体检测磷酸化MYPT1（Thr850）。
研究子类别
激酶 & 磷酸酶
激酶 & 磷酸酶
研究类别
信号传导
信号传导
Biochem/physiol Actions
Thr850磷酸化的重组截短鸡MYPT1
Physical form
在 30％ 甘油，0.07M Tris-甘氨酸，pH 7.4、0.135M NaCl 和 0.035％ 叠氮化钠作为防腐剂的溶液中的蛋白 A 纯化的兔 IgG。
形式：纯化
纯化蛋白A
Preparation Note
自收到之日起在-20°C可稳定保存2年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。
Analysis Note
对照
由ROKa/ROCK-II磷酸化的MYPT1 底物
由ROKa/ROCK-II磷酸化的MYPT1 底物
通过免疫印迹对磷酸化的MYPT1 底物进行了常规评估
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
Nandy C Lopez et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 310(11), R1053-R1063 (2016-02-26)
Exposure to high-altitude chronic hypoxia during pregnancy may cause pulmonary hypertension in neonates, as a result of vasoconstriction and vascular remodeling. We hypothesized that susceptibility to pulmonary hypertension, due to an augmented expression and activity of the RhoA/Rho-kinase (ROCK) pathway
Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery.
Soo-Kyoung Choi,Duck-Sun Ahn,Young-Ho Lee
Cardiovascular Research null
Takeshi Takagi et al.
The Journal of thoracic and cardiovascular surgery, 142(2), e59-e65 (2011-03-15)
Radial arteries are increasingly used as conduits for coronary artery bypass grafts. However, vasospasm continues to be a major concern in radial artery grafts. Rho kinase plays a critical role in vascular contraction through phosphorylation of the regulatory subunit myosin
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
Xu, EZ; Kantores, C; Ivanovska, J; Engelberts, D; Kavanagh, BP; McNamara, PJ; Jankov, RP
American Journal of Physiology. Heart and Circulatory Physiology null
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.
Nichols, RJ; Dzamko, N; Hutti, JE; Cantley, LC; Deak, M; Moran, J; Bamborough, P; Reith et al.
The Biochemical Journal null
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