生物来源
mouse
质量水平
抗体形式
ascites fluid
抗体产品类型
primary antibodies
克隆
nSyn14, monoclonal
种属反应性
human
制造商/商品名称
Upstate®
技术
immunohistochemistry: suitable
western blot: suitable
NCBI登记号
运输
dry ice
靶向翻译后修饰
nitration (Tyr39)
基因信息
human ... SNCA(6622)
一般描述
α-突触核蛋白，Mr 14.5 kDa
β-突触核蛋白，Mr 17kDa
β-突触核蛋白，Mr 17kDa
免疫原
全长重组人体外硝化的α-突触核蛋白
应用
抗硝基-α/β-突触核蛋白（Tyr39）抗体，克隆nSyn14检测硝基-α/β-突触核蛋白（Tyr39）水平&已发表 & 经验证可用于WB，IH。
研究子类别
神经退行性疾病
神经退行性疾病
研究类别
神经科学
神经科学
生化/生理作用
α-或β-Tyr39硝化的突触核蛋白
外形
含0.05％叠氮化钠的腹水
形式：纯化
腹水
制备说明
在-20°C下可保存2年
分析说明
通过免疫印迹对体外硝化的重组蛋白进行常规评估
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
Hugo Vicente Miranda et al.
Scientific reports, 7(1), 13713-13713 (2017-10-24)
Parkinson's disease (PD) is a progressive neurodegenerative disorder known for the typical motor features associated. Pathologically, it is characterized by the intracellular accumulation of alpha-synuclein (aSyn) in Lewy bodies and Lewy neurites. Currently, there are no established biochemical markers for
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
Duda, J. E., et al
Annals of Neurology, 52, 205-210 (2002)
Pedro Magalhães et al.
NPJ Parkinson's disease, 8(1), 93-93 (2022-07-23)
Parkinson's disease (PD), the second most common progressive neurodegenerative disease, develops and progresses for 10-15 years before the clinical diagnostic symptoms of the disease are manifested. Furthermore, several aspects of PD pathology overlap with other neurodegenerative diseases (NDDs) linked to
Emilio Fernández et al.
Antioxidants & redox signaling, 21(15), 2143-2148 (2014-08-16)
The research group has detected nitrosative stress and a singular version of nitrosylated serum α-synuclein in serum of Parkinson's disease (PD) patients. Dysfunction of the thyroid gland has been proposed to be linked to this disease. The aim of the
B I Giasson et al.
Science (New York, N.Y.), 290(5493), 985-989 (2000-11-04)
Aggregated alpha-synuclein proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies, and oxidative stress has been implicated in the pathogenesis of some of these disorders. Using antibodies to specific nitrated tyrosine residues in alpha-synuclein, we demonstrate extensive and widespread
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